Tìm theo
Iohexol
Các tên gọi khác (2) :
  • Iohexolum
  • N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide
Thuốc dùng chẩn đoán
Thuốc Gốc
Small Molecule
CAS: 66108-95-0
ATC: V08AB02
ĐG : GE Healthcare Inc. , http://www.gehealthcare.com
CTHH: C19H26I3N3O9
PTK: 821.1379
Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H26I3N3O9
Phân tử khối
821.1379
Monoisotopic mass
820.880309705
InChI
InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34)
InChI Key
InChIKey=NTHXOOBQLCIOLC-UHFFFAOYSA-N
IUPAC Name
1-N,3-N-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide
Traditional IUPAC Name
iohexol
SMILES
CC(=O)N(CC(O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I
Độ tan chảy
174-180 °C
Độ hòa tan
7.96e-01 g/l
logP
-3.05
logS
-3
pKa (strongest acidic)
11.73
pKa (Strongest Basic)
-3
PSA
199.89 Å2
Refractivity
148.84 m3·mol-1
Polarizability
60.37 Å3
Rotatable Bond Count
12
H Bond Acceptor Count
9
H Bond Donor Count
8
Physiological Charge
0
Number of Rings
1
Bioavailability
0
Dược Lực Học : Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
Cơ Chế Tác Dụng : Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. [PubChem] Organic iodine compounds block x-rays as they pass through the body, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. After intrathecal administration into the subarachnoid space, diffusion of iohexol in the CSF allows the visualization of the subarachnoid spaces of the head and spinal canal. After intravascular administration, iohexol makes opaque those vessels in its path of flow, allowing visualization of the internal structures until significant hemodilution occurs.
Dược Động Học :
▧ Absorption :
Small amounts are absorbed through the bladder via intravesical instillation. Following intrauterine instillation, the majority of the medium within the uterine cavity is discharged into the vagina immediately upon termination of procedure. However, any medium retained in the uterine or peritoneal cavity is absorbed systemically within 60 minutes. May not be absorbed for up to 24 hours if tubes are obstructed and dilated.
▧ Volume of Distribution :
* 350-849 mL/kg
▧ Route of Elimination :
Iohexol is absorbed from cerebrospinal fluid (CSF) into the bloodstream and is eliminated by renal excretion. No significant metabolism, deiodination, or biotransformation occurs.
▧ Half Life :
Intrathecal half-life is 3.4 hours (mean). Intravascular is approximately 2 hours (with normal renal function).
▧ Clearance :
* 109 mL/min [Adult patients receiving 16-18 ml of iohexol (180 mgI/mL) by lumbar intrathecal injection]
Độc Tính : Non-ionic radiocontrast agents like iohexol are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress.
Chỉ Định : Iohexol ia used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures.
Tương Tác Thuốc :
  • Amiodarone Increased risk of cardiotoxicity and arrhythmias
Liều Lượng & Cách Dùng : Solution - Intravascular
Solution - Intravascular
Solution - Subarachnoid
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Sigma
    Sản phẩm biệt dược : Histodenz
  • Công ty :
    Sản phẩm biệt dược : Nycodenz
  • Công ty :
    Sản phẩm biệt dược : Omnipaque
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01362
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3730
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506178
ChemSpider
http://www.chemspider.com/Chemical-Structure.3599.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0407-1401-50
PharmGKB
http://www.pharmgkb.org/drug/PA450061
Wikipedia
http://en.wikipedia.org/wiki/Iohexol
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