Tìm theo
Interferon alfa-n1
Các tên gọi khác (3) :
  • Interferon alpha-2
  • Interferon alpha-A
  • LeIF A
Thuốc chống virus
Thuốc Gốc
Biotech
CAS: 74899-72-2
ATC: L03AB06
CTHH: C860H1353N227O255S9
PTK: 19241.1000
Purified, natural (n is for natural) glycosylated human interferon alpha proteins 166 residues
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C860H1353N227O255S9
Phân tử khối
19241.1000
Độ tan chảy
61 °C
Độ kỵ nước
-0.336
Điểm đẳng điện tích
5.99
Dược Lực Học : Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.
Cơ Chế Tác Dụng : Purified, natural (n is for natural) glycosylated human interferon alpha proteins 166 residues Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
Dược Động Học :

▧ Half Life :
1.2 hours (mammalian reticulocytes, in vitro); >20 hours (yeast, in vivo); >10 hours (Escherichia coli, in vivo).
Tương Tác Thuốc :
  • Aminophylline Interferon increases the effect and toxicity of theophylline
  • Dyphylline Interferon increases the effect and toxicity of theophylline
  • Oxtriphylline Interferon increases the effect and toxicity of theophylline
  • Theophylline Interferon increases the effect and toxicity of theophylline
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00011
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/J00207
PharmGKB
http://www.pharmgkb.org/drug/PA164746538
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