Tìm theo
Interferon Alfa-2b, Recombinant
Các tên gọi khác (2) :
  • Interferon alfa-2b
  • rIFN-alpha-2b
Thuốc giảm miễn dịch
Thuốc Gốc
Biotech
CAS: 99210-65-8
ATC: L03AB05
ĐG : Physicians Total Care Inc. , http://www.physicianstotalcare.com
CTHH: C860H1353N229O255S9
PTK: 19271.0000
Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C860H1353N229O255S9
Phân tử khối
19271.0000
Độ tan chảy
61 °C
Độ kỵ nước
-0.339
Điểm đẳng điện tích
5.99
Dược Lực Học : Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.
Cơ Chế Tác Dụng : Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent. Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which upon dimerization activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
Dược Động Học :
▧ Absorption :
Absorption is high (greater than 80%) when administered intramuscularly or subcutaneously.
▧ Half Life :
The elimination half-life following both intramuscular and subcutaneous injections was approximately 2 to 3 hours. The elimination half-life was approximately 2 hours following intravenous injection.
Độc Tính : There is limited experience with overdosage. Postmarketing surveillance includes reports of patients receiving a single dose as great as 10 times the recommended dose. In general, the primary effects of an overdose are consistent with the effects seen with therapeutic doses of interferon alfa-2b. Hepatic enzyme abnormalities, renal failure, hemorrhage, and myocardial infarction have been reported with single administration overdoses and/or with longer durations of treatment than prescribed. Toxic effects after ingestion of interferon alfa-2b are not expected because interferons are poorly absorbed orally.
Chỉ Định : For the treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma.
Tương Tác Thuốc :
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Liều Lượng & Cách Dùng : Liquid - Subcutaneous
Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Schering Corp
    Sản phẩm biệt dược : Intron A
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00105
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0085-0571-02
PharmGKB
http://www.pharmgkb.org/drug/PA164783990
RxList
http://www.rxlist.com/cgi/generic/introna.htm
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