Tìm theo
Interferon Alfa-2a, Recombinant
Các tên gọi khác (3) :
  • Interferon alfa-2a
  • Oral interferon alfa
  • rIFN-alpha-2a
Thuốc Gốc
Biotech
CAS: 77907-69-8
ATC: L03AB04
ĐG : F Hoffmann La Roche Ltd. , http://www.roche.com
CTHH: C860H1353N227O255S9
PTK: 19241.1000
Interferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent. An oral form is being developed by Amarillo Biosciences.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C860H1353N227O255S9
Phân tử khối
19241.1000
Độ hòa tan
100 mg/ml
Độ kỵ nước
-0.336
Điểm đẳng điện tích
5.99
Dược Lực Học : Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.
Cơ Chế Tác Dụng : Interferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent. An oral form is being developed by Amarillo Biosciences. Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
Dược Động Học :
▧ Absorption :
Absorption is high (greater than 80%) when administered intramuscularly or subcutaneously.
▧ Volume of Distribution :
* 0.223 to 0.748 L/kg [healthy people]
▧ Route of Elimination :
Alpha-interferons are totally filtered through the glomeruli and undergo rapid proteolytic degradation during tubular reabsorption, rendering a negligible reappearance of intact alfa interferon in the systemic circulation.
▧ Half Life :
The IM half-life of interferon alfa-2a is 6 hours to 8 hours; the half-life for IV infusion is 3.7 hours to 8.5 hours (mean 5.1 hours).
▧ Clearance :
* 2.14 - 3.62 mL/min/kg [healthy]
Độc Tính : Interferon alfa-2 may cause serious adverse effects such as anemia; autoimmune diseases, including vasculitis, arthritis, hemolytic anemia, and erythematosus syndrome; cardiotoxicity; hepatotoxicity; hyperthyroidism or hypothyroidism; transient ischemic attacks; leukopenia; neurotoxicity; peripheral neuropathy; and thrombocytopenia. Some lesser side effects that may not need medical attention include blurred vision, change in taste or metallic taste, cold sores or stomatitis, diarrhea, dizziness, dry mouth, dry skin or itching, flu-like syndrome, increased sweating, leg cramps, loss of appetite, nausea or vomiting, skin rash, unusual tiredness, weight loss, and partial loss of hair.
Chỉ Định : For the treatment of chronic hepatitis C, hairy cell leukemia, AIDS-related Kaposi's sarcoma, and chronic myelogenous leukemia. Also for the treatment of oral warts arising from HIV infection.
Tương Tác Thuốc :
  • Aminophylline Interferon increases the effect and toxicity of theophylline
  • Dyphylline Interferon increases the effect and toxicity of theophylline
  • Oxtriphylline Interferon increases the effect and toxicity of theophylline
  • Theophylline Interferon increases the effect and toxicity of theophylline
Liều Lượng & Cách Dùng : Injection, solution - Subcutaneous
Injection, solution - Subcutaneous
Lozenge - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00034
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0004-2015-09
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/J00207
PharmGKB
http://www.pharmgkb.org/drug/PA164779048
RxList
http://www.rxlist.com/cgi/generic3/roferon.htm
Drugs.com
http://www.drugs.com/cdi/interferon-alfa-2a-solution.html
... loading
... loading