Tìm theo
Hydroxychloroquine
Các tên gọi khác (14 ) :
  • (+-)-Hydroxychloroquine
  • (±)-hydroxychloroquine
  • 2-((4-((7-chloro-4-Quinolyl)amino)pentyl)ethylamino)ethanol
  • 2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol
  • 7-chloro-4-(4-(Ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline
  • 7-chloro-4-(4-(N-Ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline
  • 7-chloro-4-[4-(N-Ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline
  • 7-chloro-4-[5-(N-Ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline
  • Hidroxicloroquina
  • Hydroxychloroquinum
  • NSC4375
  • Oxichlorochine
  • Oxichloroquine
  • Polirreumin
Thuốc giảm đau, hạ sốt, chống viêm không steroid, điều trị Gút và các bệnh xương khớp
Thuốc Gốc
Small Molecule
CAS: 118-42-3
ĐG : Amerisource Health Services Corp. , http://www.amerisourcebergen.com
CTHH: C18H26ClN3O
PTK: 335.872
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H26ClN3O
Phân tử khối
335.872
Monoisotopic mass
335.176440176
InChI
InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)
InChI Key
InChIKey=XXSMGPRMXLTPCZ-UHFFFAOYSA-N
IUPAC Name
2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol
Traditional IUPAC Name
hydroxychloroquine
SMILES
CCN(CCO)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
Độ tan chảy
89-91
Độ hòa tan
2.61e-02 g/l
logP
2.89
logS
-4.1
pKa (strongest acidic)
15.59
pKa (Strongest Basic)
9.76
PSA
48.39 Å2
Refractivity
97.97 m3·mol-1
Polarizability
38.3 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
2
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Hydroxychloroquine possesses antimalarial properties and also exerts a beneficial effect in lupus erythematosus (chronic discoid or systemic) and acute or chronic rheumatoid arthritis. The precise mechanism of action is not known.
Cơ Chế Tác Dụng : A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Although the exact mechanism of action is unknown, it may be based on ability of hydroxychloroquine to bind to and alter DNA. Hydroxychloroquine has also has been found to be taken up into the acidic food vacuoles of the parasite in the erythrocyte. This increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. In suppressive treatment, hydroxychloroquine inhibits the erythrocytic stage of development of plasmodia. In acute attacks of malaria, it interrupts erythrocytic schizogony of the parasite. Its ability to concentrate in parasitized erythrocytes may account for their selective toxicity against the erythrocytic stages of plasmodial infection. As an antirheumatic, hydroxychloroquine is thought to act as a mild immunosuppressant, inhibiting the production of rheumatoid factor and acute phase reactants. It also accumulates in white blood cells, stabilizing lysosomal membranes and inhibiting the activity of many enzymes, including collagenase and the proteases that cause cartilage breakdown.
Dược Động Học :
▧ Absorption :
Very rapidly and completely absorbed following oral administration.
▧ Protein binding :
Approximately 45%.
▧ Metabolism :
Partially hepatic, to active de-ethylated metabolites.
▧ Half Life :
Terminal elimination half-life In blood is approximately 50 days. In plasma it is approximately 32 days.
Độc Tính : Symptoms of overdose include headache, drowsiness, visual disturbances, cardiovascular collapse, and convulsions, followed by sudden and early respiratory and cardiac arrest. The electrocardiogram may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, and progressive bradycardia leading to ventricular fibrillation and/or arrest.
Chỉ Định : For the suppressive treatment and treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis.
Tương Tác Thuốc :
  • Artemether Hydroxychloroquine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
  • Digoxin Hydroxychloroquine increases the effect of digoxin
  • Lumefantrine Hydroxychloroquine may increase the adverse effects of lumefantrine. Combination therapy is contraindicated unless there are no other treatment options.
  • Methotrexate Hydroxychloroquine increases the effect and toxicity of methotrexate
  • Rilonacept results in increased immunosuppressive effects; increases the risk of infection.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : AstraZeneca
    Sản phẩm biệt dược : Axokine
  • Công ty : Inmunosyn
    Sản phẩm biệt dược : Dolquine
  • Công ty : Medigroup
    Sản phẩm biệt dược : HCQS
  • Công ty : Sanofi
    Sản phẩm biệt dược : Plaquenil
  • Công ty : TRB
    Sản phẩm biệt dược : Polirreumin
  • Công ty : Sanofi
    Sản phẩm biệt dược : Quensyl
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01611
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3652
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508459
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07043
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D08050
ChemSpider
http://www.chemspider.com/Chemical-Structure.3526.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0955-0790-01
PharmGKB
http://www.pharmgkb.org/drug/PA164777036
Wikipedia
http://en.wikipedia.org/wiki/Hydroxychloroquine
RxList
http://www.rxlist.com/cgi/generic/hquine.htm
Drugs.com
http://www.drugs.com/cdi/hydroxychloroquine.html
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