Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Dược Lực Học :
Hyaluronidase hydrolyzes hyaluronic acid and increase diffusion of injected drugs, thus facilitating their absorption. Hyaluronidase is used for enhancing absorption and distribution of other injected drugs.
Cơ Chế Tác Dụng :
Highly purified sheep hyaluronidase for administration by injection into the vitreous of the eye.
Hyaluronidase is a spreading or diffusing substance. It increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.
Chỉ Định :
For increase of absorption and distribution of other injected drugs and for rehydration.
Tương Tác Thuốc :
Consider modifying therapy due to enhanced adverse effects of dopamine.
Avoid combination because hyaluronidase can potentiate the vasoconstrictive effect of phenylephrine.
Tài Liệu Tham Khảo Thêm
National Drug Code Directory