Tìm theo
Halothane
Các tên gọi khác (14 ) :
  • 1-Bromo-1-chloro-2,2,2-trifluoroethane
  • 1,1,1-Trifluoro-2-bromo-2-chloroethane
  • 1,1,1-Trifluoro-2-chloro-2-bromoethane
  • 2-Bromo-2-Chloro-1,1,1-Trifluoroethane
  • 2,2,2-Trifluoro-1-chloro-1-bromoethane
  • Bromochlorotrifluoroethane
  • Fluothane
  • Ftorotan
  • Halotano
  • Halothane
  • Halothanum
  • Narcotane
  • Phthorothanum
  • Rhodialothan
Thuốc gây tê, mê
Thuốc Gốc
Small Molecule
CAS: 151-67-7
ATC: N01AB01
ĐG : Halocarbon Laboratories , http://www.halocarbon.com
CTHH: C2HBrClF3
PTK: 197.382
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2HBrClF3
Phân tử khối
197.382
Monoisotopic mass
195.890225001
InChI
InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H
InChI Key
InChIKey=BCQZXOMGPXTTIC-UHFFFAOYSA-N
IUPAC Name
2-bromo-2-chloro-1,1,1-trifluoroethane
Traditional IUPAC Name
halothane
SMILES
FC(F)(F)C(Cl)Br
Độ tan chảy
50-50.5
Độ sôi
50.2 °C
Độ hòa tan
4070 mg/L (at 25 °C)
logP
2.30
logS
-1.71
Refractivity
24.63 m3·mol-1
Polarizability
9.78 Å3
Polar Surface Area (PSA)
0
Rotatable Bond Count
1
H Bond Acceptor Count
0
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Cơ Chế Tác Dụng : A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178) Halothane causes general anaethesia due to its actions on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility. Its immobilizing effects have been attributed to its binding to potassium channels in cholinergic neurons. Halothane's effect are also likely due to binding to NMDA and calcium channels, causing hyperpolarization.
Dược Động Học :

▧ Metabolism :
Halothane is metabolized in the liver, primarily by CYP2E1, and to a lesser extent by CYP3A4 and CYP2A6.
Độc Tính : Toxic effects of halothane include malignant hyperthermia and hepatitis.
Chỉ Định : For the induction and maintenance of general anesthesia
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Liquid - Respiratory (inhalation)
Solution - Respiratory (inhalation)
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Halothane liquid
    Giá bán buôn : USD >0.24
    Đơn vị tính : ml
Nhà Sản Xuất
  • Công ty : Ayerst
    Sản phẩm biệt dược : Fluothane
  • Công ty : Jugoremedija
    Sản phẩm biệt dược : Halotan
  • Công ty : Zentiva
    Sản phẩm biệt dược : Narcotan
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01159
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3562
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506589
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07515
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00542
ChemSpider
http://www.chemspider.com/Chemical-Structure.3441.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0409-4894-02
PharmGKB
http://www.pharmgkb.org/drug/PA449845
Wikipedia
http://en.wikipedia.org/wiki/Halothane
RxList
http://www.rxlist.com/cgi/generic2/halothane.htm
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