Tìm theo
Fluoxymesterone
Các tên gọi khác (8 ) :
  • 11beta,17beta-Dihydroxy-9alpha-fluoro-17alpha-methyl-4-androster-3-one
  • 17alpha-Methyl-9alpha-fluoro-11beta-hydroxytesterone
  • 17α-Methyl-9α-fluoro-11β-hydroxytesterone
  • 9-Fluoro-11beta,17beta-dihydroxy-17-methylandrost-4-en-3-one
  • 9alpha-Fluoro-11beta-hydroxy-17-methyltestosterone
  • Fluoximesterona
  • Fluoxymesteronum
  • Testosterone, 9-fluoro-11beta-hydroxy-17-methyl-
anabolic agents
Thuốc Gốc
Small Molecule
CAS: 76-43-7
ATC: G03BA01
ĐG : Major Pharmaceuticals , http://www.majorpharmaceuticals.com
CTHH: C20H29FO3
PTK: 336.4409
An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H29FO3
Phân tử khối
336.4409
Monoisotopic mass
336.210072999
InChI
InChI=1S/C20H29FO3/c1-17-8-6-13(22)10-12(17)4-5-15-14-7-9-19(3,24)18(14,2)11-16(23)20(15,17)21/h10,14-16,23-24H,4-9,11H2,1-3H3/t14-,15-,16-,17-,18-,19-,20-/m0/s1
InChI Key
InChIKey=YLRFCQOZQXIBAB-RBZZARIASA-N
IUPAC Name
(1R,2S,10S,11S,14S,15S,17S)-1-fluoro-14,17-dihydroxy-2,14,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Traditional IUPAC Name
fluoxymesterone
SMILES
[H][C@@]12CC[C@](C)(O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Độ tan chảy
265
Độ hòa tan
67.5 mg/L
logP
2.38
logS
-3.9
pKa (strongest acidic)
13.6
pKa (Strongest Basic)
-3
PSA
57.53 Å2
Refractivity
90.19 m3·mol-1
Polarizability
36.63 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Fluoxymesterone is a synthetic androgen, or male hormone, similar to testosterone. Fluoxymesterone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.
Cơ Chế Tác Dụng : An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. [PubChem] Fluoxymesterone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, fluoxymesterone binds to the androgen receptor. It produces retention of nitrogen, sodium, potassium, and phosphorus; increases protein anabolism; decreases amino acid catabolism and decreased urinary excretion of calcium. The antitumour activity of fluoxymesterone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Dược Động Học :
▧ Absorption :
Oral absorption is less than 44%.
▧ Protein binding :
Very high (99%) with 80% to sex hormone binding globulin, 19% to albumin.
▧ Metabolism :
Presence of 17-alpha alkyl group reduces susceptibility to hepatic enzyme degradation, which slows metabolism and allows oral administration. Inactivation of testosterone occurs primarily in the liver
▧ Half Life :
9.2 hours
Độc Tính : Side effects include virilization (masculine traits in women), acne, fluid retention, and hypercalcemia.
Chỉ Định : In males, used as replacement therapy in conditions associated with symptoms of deficiency or absence of endogenous testosterone. In females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
Tương Tác Thuốc :
  • Acenocoumarol The androgen, fluoxymesterone, may increase the anticoagulant effect of acenocoumarol.
  • Anisindione The androgen, fluoxymesterone, may increase the anticoagulant effect of anisindione.
  • Dicoumarol The androgen, fluoxymesterone, may increase the anticoagulant effect of dicumarol.
  • Warfarin Fluoxymesterone may increase the serum concentration and anticoagulant effect of warfarin. Monitor for changes in prothrombin time and therapeutic effects of warfarin if fluoxymesterone is initiated, discontinued or dose changed.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Androxy
  • Công ty : Upjohn
    Sản phẩm biệt dược : Halotestin
  • Sản phẩm biệt dược : Ora-Testryl
  • Công ty : Midy
    Sản phẩm biệt dược : Testoral
  • Công ty : Upjohn
    Sản phẩm biệt dược : U-Gono
  • Công ty : Ciba
    Sản phẩm biệt dược : UItandren
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01185
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6446
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508867
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00327
ChemSpider
http://www.chemspider.com/Chemical-Structure.6205.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18189
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0009-0014-01
PharmGKB
http://www.pharmgkb.org/drug/PA164744518
Wikipedia
http://en.wikipedia.org/wiki/Fluoxymesterone
RxList
http://www.rxlist.com/cgi/generic2/fluoxy.htm
Drugs.com
http://www.drugs.com/cdi/fluoxymesterone.html
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