Tìm theo
Flunitrazepam
Các tên gọi khác (2) :
  • Flunitrazepamum
  • Rohypnol
Thuốc chống lo âu, hoảng sợ
Thuốc Gốc
Small Molecule
CAS: 1622-62-4
ATC: N05CD03
CTHH: C16H12FN3O3
PTK: 313.2832
A benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H12FN3O3
Phân tử khối
313.2832
Monoisotopic mass
313.08626947
InChI
InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3
InChI Key
InChIKey=PPTYJKAXVCCBDU-UHFFFAOYSA-N
IUPAC Name
5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Traditional IUPAC Name
flunitrazepam
SMILES
CN1C2=C(C=C(C=C2)[N+]([O-])=O)C(=NCC1=O)C1=CC=CC=C1F
Độ tan chảy
166-167 °C
Độ hòa tan
8.58e-03 g/l
logP
2.06
logS
-4.6
pKa (Strongest Basic)
1.7
PSA
78.49 Å2
Refractivity
82.55 m3·mol-1
Polarizability
29.6 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
4
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Flunitrazepam is a powerful hypnotic drug that is a benzodiazepine derivative. It has powerful hypnotic, sedative, anxiolytic, and skeletal muscle relaxant properties. The drug is sometimes used as a date rape drug. In the United States, the drug has not been approved by the Food and Drug Administration for medical use, and is considered to be an illegal drug. It has however been approved in the United Kingdom and other countries.
Cơ Chế Tác Dụng : A benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. [PubChem] Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
Dược Động Học :
▧ Absorption :
50% (suppository) and 64-77% (oral)
▧ Metabolism :
Hepatic.
▧ Half Life :
18-26 hours
Độc Tính : Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.
Chỉ Định : For short-term treatment of severe insomnias, that are not responsive to other hypnotics.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Roche
    Sản phẩm biệt dược : Hipnosedon
  • Công ty : Alphapharm
    Sản phẩm biệt dược : Hypnodorm
  • Công ty : Roche
    Sản phẩm biệt dược : Narcozep
  • Công ty : Roche
    Sản phẩm biệt dược : Rohypnol
  • Công ty : Roche
    Sản phẩm biệt dược : Roipnol
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01544
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3380
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504553
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01230
ChemSpider
http://www.chemspider.com/Chemical-Structure.3263.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25878
PharmGKB
http://www.pharmgkb.org/drug/PA164781320
Wikipedia
http://en.wikipedia.org/wiki/Flunitrazepam
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