Tìm theo
Fenoterol
Các tên gọi khác (6 ) :
  • 1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-((4-hydroxyphenyl)isopropylamino)ethane
  • 1-(P-Hydroxyphenyl)-2-((beta-hydroxy-beta-(3',5'-dihydroxyphenyl))ethyl)aminopropane
  • 3,5-Dihydroxy-alpha-(((P-hydroxy-alpha-methylphenethyl)amino)methyl)benzyl alcohol
  • 5-{1-hydroxy-2-[2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-benzene-1,3-diol
  • Fenoterolum
  • Phenoterol
Thuốc tác dụng trên đường hô hấp
Thuốc Gốc
Small Molecule
CAS: 13392-18-2
ATC: R03CC04, G02CA03, R03AC04
CTHH: C17H21NO4
PTK: 303.3529
An adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H21NO4
Phân tử khối
303.3529
Monoisotopic mass
303.147058165
InChI
InChI=1S/C17H21NO4/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13/h2-5,7-9,11,17-22H,6,10H2,1H3
InChI Key
InChIKey=LSLYOANBFKQKPT-UHFFFAOYSA-N
IUPAC Name
5-(1-hydroxy-2-{[1-(4-hydroxyphenyl)propan-2-yl]amino}ethyl)benzene-1,3-diol
Traditional IUPAC Name
fenoterol
SMILES
CC(CC1=CC=C(O)C=C1)NCC(O)C1=CC(O)=CC(O)=C1
Độ tan chảy
222-223
Độ hòa tan
1.62e-01 g/l
logP
1.47
logS
-3.3
pKa (strongest acidic)
8.85
pKa (Strongest Basic)
9.63
PSA
92.95 Å2
Refractivity
85 m3·mol-1
Polarizability
31.75 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
5
H Bond Donor Count
5
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Fenoterol is a beta agonist designed to open up the airways to the lungs by decreasing bronchconstriction.
Cơ Chế Tác Dụng : An adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic. [PubChem] Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.
Dược Động Học :

▧ Metabolism :
Hepatic.
Độc Tính : Symptoms of overdose include angina (chest pain), dizziness, dry mouth, fatigue, flu-like symptoms, headache, heart irregularities, high or low blood pressure, high blood sugar, insomnia, muscle cramps, nausea, nervousness, rapid heartbeat, seizures, and tremor.
Chỉ Định : Fenoterol is used for the treatment of asthma.
Tương Tác Thuốc :
  • Acebutolol Antagonism
  • Alseroxylon Increased arterial pressure
  • Amitriptyline The tricyclic antidepressant, amitriptyline, may increase the sympathomimetic effect of fenoterol.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of fenoterol.
  • Atenolol Antagonism
  • Betaxolol Beta-Blockers (Beta-1 Selective) like betaxolol may diminish the bronchodilatory effect of Beta2-Agonists like fenoterol. Therapy should be monitored.
  • Bevantolol Antagonism
  • Bisoprolol Antagonism
  • Carteolol Antagonism
  • Carvedilol Antagonism
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of fenoterol.
  • Deserpidine Increased arterial pressure
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of fenoterol.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of fenoterol.
  • Esmolol Antagonism
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of fenoterol.
  • Isocarboxazid Increased arterial pressure
  • Labetalol Antagonism
  • Linezolid Possible increase of arterial pressure
  • Methyldopa Increased arterial pressure
  • Metoprolol Antagonism
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of fenoterol.
  • Nadolol Antagonism
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of fenoterol.
  • Oxprenolol Antagonism
  • Pargyline Increased arterial pressure
  • Penbutolol Antagonism
  • Phenelzine Increased arterial pressure
  • Pindolol Antagonism
  • Practolol Antagonism
  • Propranolol Antagonism
  • Protriptyline The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of fenoterol.
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
  • Sotalol Antagonism
  • Timolol Antagonism
  • Tranylcypromine Increased arterial pressure
  • Trimipramine The tricyclic antidepressant, trimipramine, increases the sympathomimetic effect of fenoterol.
Liều Lượng & Cách Dùng : Aerosol, metered - Respiratory (inhalation)
Aerosol, metered - Respiratory (inhalation)
Solution - Respiratory (inhalation)
Solution - Respiratory (inhalation)
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01288
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3343
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509099
ChemSpider
http://www.chemspider.com/Chemical-Structure.3226.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131281
PharmGKB
http://www.pharmgkb.org/drug/PA10079
Wikipedia
http://en.wikipedia.org/wiki/Fenoterol
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