Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Traditional IUPAC Name
pKa (strongest acidic)
pKa (Strongest Basic)
Dược Lực Học :
Ethchlorvynol is a sedative drug and schedule IV (USA) controlled substance. It produces cerebral depression, however the exact mechanism of action is not known.
Cơ Chế Tác Dụng :
Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. [Wikipedia]
Although the exact mechanism of action is unknown, ethchlorvynol appears to depress the central nervous system in a manner similar to that of barbiturates. Barbiturates bind at a distinct binding sites associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Dược Động Học :
▧ Absorption :
Rapidly absorbed from gastrointestinal tract.
▧ Protein binding :
▧ Metabolism :
About 90% of a dose is metabolized in the liver. Some ethchlorvynol may also be metabolized in the kidneys. Ethchlorvynol and metabolites undergo extensive enterohepatic recirculation.
▧ Half Life :
Plasma half-life is approximately 10 to 20 hours, terminal half-life is 21-100 hours.
Độc Tính :
Symptoms of overdose include thrombocytopenia.
Chỉ Định :
Used for short-term hypnotic therapy in the management of insomnia for periods of up to one week in duration; however, this medication generally has been replaced by other sedative-hypnotic agents.
Tương Tác Thuốc :
Ethchlorvynol may decrease the anticoagulant effect of acenocoumarol.
Ethchlorvynol may decrease the anticoagulant effect of anisindione.
Ethchlorvynol may decrease the anticoagulant effect of dicumarol.
Ethchlorvynol may decrease the anticoagulant effect of warfarin.
Liều Lượng & Cách Dùng :
Capsule - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
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Sản phẩm biệt dược : Serenesil