Tìm theo
Ethchlorvynol
Các tên gọi khác (7 ) :
  • 1-chloro-3-ethyl-1-penten-4-yn-3-ol
  • 1-Chloro-3-ethyl-pent-1-en-4-yn-3-ol
  • 3-(beta-chlorovinyl)-1-pentyn-3-ol
  • 3-(β-chlorovinyl)-1-pentyn-3-ol
  • ethyl β-chlorovinyl ethynyl carbinol
  • Placidyl
  • β-chlorovinyl ethyl ethynyl carbinol
Thuốc an thần
Thuốc Gốc
Small Molecule
CAS: 113-18-8
ATC: N05CM08
CTHH: C7H9ClO
PTK: 144.599
Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C7H9ClO
Phân tử khối
144.599
Monoisotopic mass
144.034192617
InChI
InChI=1S/C7H9ClO/c1-3-7(9,4-2)5-6-8/h1,5-6,9H,4H2,2H3/b6-5+
InChI Key
InChIKey=ZEHYJZXQEQOSON-AATRIKPKSA-N
IUPAC Name
1-chloro-3-ethylpent-1-en-4-yn-3-ol
Traditional IUPAC Name
ethchlorvynol
SMILES
[H]C(Cl)=CC(O)(CC)C#C
Độ sôi
28.5-30
Độ hòa tan
1.43e-01 g/l
logP
1.8
logS
-3
pKa (strongest acidic)
12.88
pKa (Strongest Basic)
-3.7
PSA
20.23 Å2
Refractivity
38.64 m3·mol-1
Polarizability
14.77 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Ethchlorvynol is a sedative drug and schedule IV (USA) controlled substance. It produces cerebral depression, however the exact mechanism of action is not known.
Cơ Chế Tác Dụng : Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. [Wikipedia] Although the exact mechanism of action is unknown, ethchlorvynol appears to depress the central nervous system in a manner similar to that of barbiturates. Barbiturates bind at a distinct binding sites associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Dược Động Học :
▧ Absorption :
Rapidly absorbed from gastrointestinal tract.
▧ Protein binding :
35-50%
▧ Metabolism :
About 90% of a dose is metabolized in the liver. Some ethchlorvynol may also be metabolized in the kidneys. Ethchlorvynol and metabolites undergo extensive enterohepatic recirculation.
▧ Half Life :
Plasma half-life is approximately 10 to 20 hours, terminal half-life is 21-100 hours.
Độc Tính : Symptoms of overdose include thrombocytopenia.
Chỉ Định : Used for short-term hypnotic therapy in the management of insomnia for periods of up to one week in duration; however, this medication generally has been replaced by other sedative-hypnotic agents.
Tương Tác Thuốc :
  • Acenocoumarol Ethchlorvynol may decrease the anticoagulant effect of acenocoumarol.
  • Anisindione Ethchlorvynol may decrease the anticoagulant effect of anisindione.
  • Dicoumarol Ethchlorvynol may decrease the anticoagulant effect of dicumarol.
  • Warfarin Ethchlorvynol may decrease the anticoagulant effect of warfarin.
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Pfizer
    Sản phẩm biệt dược : Arvynol
  • Công ty : Dainippon
    Sản phẩm biệt dược : Nostel
  • Công ty : Abbott
    Sản phẩm biệt dược : Placidyl
  • Công ty : Pfizer-Roerig
    Sản phẩm biệt dược : Roeridorm
  • Công ty : Abbott
    Sản phẩm biệt dược : Serenesil
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00189
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07833
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00704
PharmGKB
http://www.pharmgkb.org/drug/PA164746383
Wikipedia
http://en.wikipedia.org/wiki/Ethchlorvynol
Drugs.com
http://www.drugs.com/cons/ethchlorvynol.html
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