Tìm theo
Ephedra
Các tên gọi khác (3) :
  • Chinese jointfir
  • Indian jointfir
  • Ma huang
Thuốc Gốc
Small Molecule
Ephedra is an alkaloid chemical compound traditionally obtained from the plant Ephedra sinica. The sale of ephedra-containing supplements was banned in the United States in 2004. The drug is still sold in Canada in OTC formulations.
Cơ Chế Tác Dụng : Ephedra is an alkaloid chemical compound traditionally obtained from the plant Ephedra sinica. The sale of ephedra-containing supplements was banned in the United States in 2004. The drug is still sold in Canada in OTC formulations. The alkaloids ephedrine and pseudoephedrine are the active constituents of Ephedra. Pseudoephedrine is used in over-the-counter decongestants. Derivatives of ephedrine are used to treat low blood pressure, but alternatives with reduced cardiovascular risk have replaced it for treating asthma. Ephedrine is also considered a performance-enhancing drug and is prohibited in most competitive sports. Ephedrine is a sympathomimetic amine - that is, its principal mechanism of action relies on its direct and indirect actions on the adrenergic receptor system, which is part of the sympathetic nervous system. Ephedrine increases post-synaptic noradrenergic receptor activity by (weakly) directly activating post-synaptic α-receptors and β-receptors, but the bulk of its effect comes from the pre-synaptic neuron being unable to distinguish between real adrenaline or noradrenaline from ephedrine. The ephedrine, mixed with noradrenaline, is transported through the noradrenaline reuptake complex and packaged (along with real noradrenaline) into vesicles that reside at the terminal button of a nerve cell. Ephedrine's action as an agonist at most major noradrenaline receptors and its ability to increase the release of both dopamine and to a lesser extent, serotonin by the same mechanism is presumed to have a major role in its mechanism of action.
Chỉ Định : Ephedra is widely used by athletes, despite a lack of evidence that it enhances athletic performance. Ephedra has also been used for weight loss.
Tương Tác Thuốc :
  • Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of ephedra.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of ephedra.
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of ephedra.
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of ephedra.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of ephedra.
  • Guanethidine Ephedra may decrease the effect of guanethidine.
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of ephedra.
  • Isocarboxazid Increased arterial pressure
  • Linezolid Possible increase of arterial pressure
  • Methyldopa Increased arterial pressure
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of ephedra.
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of ephedra.
  • Phenelzine Increased arterial pressure
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
  • Trandolapril Ephedra may antagonize the antihypertensive effect of Trandolapril. Monitor Trandolapril efficacy.
Liều Lượng & Cách Dùng : Capsule - Oral
Liquid - Oral
Powder, for solution - Oral
Solution / drops - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Ephedra vulgaris
  • Công ty :
    Sản phẩm biệt dược : Sinueaze
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01363
PharmGKB
http://www.pharmgkb.org/drug/PA164777031
Wikipedia
http://en.wikipedia.org/wiki/Ephedra
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/herbaldrugs/101040.shtml
Drugs.com
http://www.drugs.com/cdi/ephedra.html
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