Tìm theo
Dopamine
Các tên gọi khác (16 ) :
  • 2-(3,4-Dihydroxyphenyl)ethylamine
  • 3-Hydroxytyramine
  • 3,4-Dihydroxyphenethylamine
  • 4-(2-Aminoethyl)-1,2-benzenediol
  • 4-(2-Aminoethyl)benzene-1,2-diol
  • 4-(2-Aminoethyl)catechol
  • 4-(2-Aminoethyl)pyrocatechol
  • Deoxyepinephrine
  • Dopamin
  • Dopamina
  • Dopamine
  • Dopaminum
  • Dophamine
  • Hydroxytyramin
  • Hydroxytyramine
  • Oxytyramine
Thuốc tim mạch
Thuốc Gốc
Small Molecule
CAS: 51-61-6
ATC: C01CA04
ĐG : American Regent , http://www.americanregent.com
CTHH: C8H11NO2
PTK: 153.1784
One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H11NO2
Phân tử khối
153.1784
Monoisotopic mass
153.078978601
InChI
InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
InChI Key
InChIKey=VYFYYTLLBUKUHU-UHFFFAOYSA-N
IUPAC Name
4-(2-aminoethyl)benzene-1,2-diol
Traditional IUPAC Name
dopamine
SMILES
NCCC1=CC(O)=C(O)C=C1
Độ tan chảy
128 °C
Độ sôi
227 °C at 2.30E+01 mm Hg
Độ hòa tan
600 g/L
logP
-0.98
logS
-1.3
pKa (strongest acidic)
10.01
pKa (Strongest Basic)
9.27
PSA
66.48 Å2
Refractivity
43.25 m3·mol-1
Polarizability
16.21 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
3
H Bond Donor Count
3
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
caco2 Permeability
-5.03
pKa
8.93
Dược Lực Học : Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings.
Cơ Chế Tác Dụng : One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. [PubChem] Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. In the brain, dopamine actas as an agonist to the five dopamine receptor subtypes (D!, D2, D3, D4, D5).
Dược Động Học :
▧ Absorption :
Dopamine is rapidly absorbed from the small intestine.
▧ Protein binding :
No information currently available on protein binding.
▧ Metabolism :
Biotransformation of dopamine proceeds rapidly to yield the principal excretion products, 3-4-dihydroxy-phenylacetic acid (DOPAC) and 3-methoxy-4-hydroxy-phenylacetic acid (homovanillic acid, HVA).
▧ Route of Elimination :
It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid. A very small portion is excreted unchanged.
▧ Half Life :
2 minutes
Độc Tính : LD50 oral mice = 1460 mg/kg, LD50 oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.
Chỉ Định : For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure
Tương Tác Thuốc :
  • Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect, dopamine.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of dopamine.
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of dopamine.
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of dopamine.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of dopamine.
  • Entacapone Entacapone increases the effect and toxicity of the sympathomimetic, dopamine.
  • Fosphenytoin Risk of severe hypotension
  • Guanethidine Dopamine may decrease the effect of guanethidine.
  • Hyaluronidase Consider modifying therapy due to enhanced adverse effects of dopamine.
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of dopamine.
  • Isocarboxazid Increased arterial pressure
  • Linezolid Possible increase of arterial pressure
  • Lurasidone Dopamine increases toxicity (enhanced hypotensive effects) of lurasidone.
  • Methyldopa Increased arterial pressure
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of dopamine.
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of dopamine.
  • Phenelzine Increased arterial pressure
  • Phenytoin Risk of severe hypotension
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
Liều Lượng & Cách Dùng : Injection, solution, concentrate - Intravenous drip
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Intropin
  • Công ty :
    Sản phẩm biệt dược : Revimine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00988
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=681
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506043
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C03758
ChemSpider
http://www.chemspider.com/Chemical-Structure.661.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0517-1805-25
PharmGKB
http://www.pharmgkb.org/drug/PA449396
Wikipedia
http://en.wikipedia.org/wiki/Dopamine
RxList
http://www.rxlist.com/cgi/generic3/dopamine.htm
Drugs.com
http://www.drugs.com/cdi/dopamine.html
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