Dopamine

Các tên gọi khác (16 ) :

2-(3,4-Dihydroxyphenyl)ethylamine
3-Hydroxytyramine
3,4-Dihydroxyphenethylamine
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
Deoxyepinephrine
Dopamin
Dopamina
Dopamine
Dopaminum
Dophamine
Hydroxytyramin
Hydroxytyramine
Oxytyramine

Thuốc tim mạch

Thuốc Gốc

Small Molecule

CAS: 51-61-6

ATC: C01CA04

ĐG : American Regent , http://www.americanregent.com

CTHH: C₈H₁₁NO₂

PTK: 153.1784

One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. [PubChem]

Nhận Dạng Quốc Tế & Đặc Tính Hóa Học

Công thức hóa học

C₈H₁₁NO₂

Phân tử khối

153.1784

Monoisotopic mass

153.078978601

InChI

InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2

InChI Key

InChIKey=VYFYYTLLBUKUHU-UHFFFAOYSA-N

IUPAC Name

4-(2-aminoethyl)benzene-1,2-diol

Traditional IUPAC Name

dopamine

SMILES

NCCC1=CC(O)=C(O)C=C1

Độ tan chảy

128 °C

Độ sôi

227 °C at 2.30E+01 mm Hg

Độ hòa tan

600 g/L

logP

-0.98

logS

-1.3

pKa (strongest acidic)

10.01

pKa (Strongest Basic)

9.27

PSA

66.48 Å²

Refractivity

43.25 m³·mol^-1

Polarizability

16.21 Å³

Rotatable Bond Count

H Bond Acceptor Count

H Bond Donor Count

Physiological Charge

Number of Rings

Bioavailability

Rule of Five

true

caco2 Permeability

-5.03

pKa

8.93

Dược Lực Học : Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings.

Cơ Chế Tác Dụng : One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. [PubChem] Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. In the brain, dopamine actas as an agonist to the five dopamine receptor subtypes (D!, D2, D3, D4, D5).

Dược Động Học :

▧ Absorption :
Dopamine is rapidly absorbed from the small intestine.
▧ Protein binding :
No information currently available on protein binding.
▧ Metabolism :
Biotransformation of dopamine proceeds rapidly to yield the principal excretion products, 3-4-dihydroxy-phenylacetic acid (DOPAC) and 3-methoxy-4-hydroxy-phenylacetic acid (homovanillic acid, HVA).
▧ Route of Elimination :
It has been reported that about 80% of the drug is excreted in the urine within 24 hours, primarily as HVA and its sulfate and glucuronide conjugates and as 3,4-dihydroxyphenylacetic acid. A very small portion is excreted unchanged.
▧ Half Life :
2 minutes

Độc Tính : LD₅₀ oral mice = 1460 mg/kg, LD₅₀ oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.

Chỉ Định : For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure

Tương Tác Thuốc :

Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect, dopamine.
Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of dopamine.
Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of dopamine.
Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of dopamine.
Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of dopamine.
Entacapone Entacapone increases the effect and toxicity of the sympathomimetic, dopamine.
Fosphenytoin Risk of severe hypotension
Guanethidine Dopamine may decrease the effect of guanethidine.
Hyaluronidase Consider modifying therapy due to enhanced adverse effects of dopamine.
Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of dopamine.
Isocarboxazid Increased arterial pressure
Linezolid Possible increase of arterial pressure
Lurasidone Dopamine increases toxicity (enhanced hypotensive effects) of lurasidone.
Methyldopa Increased arterial pressure
Midodrine Increased arterial pressure
Moclobemide Moclobemide increases the sympathomimetic effect of dopamine.
Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of dopamine.
Phenelzine Increased arterial pressure
Phenytoin Risk of severe hypotension
Rasagiline Increased arterial pressure
Reserpine Increased arterial pressure

Liều Lượng & Cách Dùng : Injection, solution, concentrate - Intravenous drip

Dữ Kiện Thương Mại

Giá thị trường

Biệt dược thương mại : Dopamine 400 mg-d5w 250 ml

Giá bán buôn : USD >0.04

Đơn vị tính : ml
Biệt dược thương mại : Dopamine 800 mg-d5w 500 ml

Giá bán buôn : USD >0.05

Đơn vị tính : ml
Biệt dược thương mại : Dopamine 40 mg/ml vial

Giá bán buôn : USD >0.15

Đơn vị tính : ml

Nhà Sản Xuất

Công ty :

Sản phẩm biệt dược : Intropin
Công ty :

Sản phẩm biệt dược : Revimine

Đóng gói

Công ty : American Regent

Website : http://www.americanregent.com
Công ty : B. Braun Melsungen AG

Website : http://www.bbraun.com
Công ty : Baxter International Inc.

Website : http://www.baxter.com
Công ty : Bristol-Myers Squibb Co.

Website : http://www.bms.com
Công ty : Cardinal Health

Website : http://www.cardinal.com
Công ty : General Injectables and Vaccines Inc.

Website : http://www.giv.com
Công ty : Hospira Inc.

Website : http://www.hospira.com
Công ty : Luitpold Pharmaceuticals Inc.

Website : http://www.luitpold.com
Công ty : Physicians Total Care Inc.

Website : http://www.physicianstotalcare.com

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB00988

PubChem Compound

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=681

PubChem Substance

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506043

KEGG Compound

http://www.genome.jp/dbget-bin/www_bget?cpd:C03758

ChemSpider

http://www.chemspider.com/Chemical-Structure.661.html

National Drug Code Directory

http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0517-1805-25

PharmGKB

http://www.pharmgkb.org/drug/PA449396

Wikipedia

http://en.wikipedia.org/wiki/Dopamine

RxList

http://www.rxlist.com/cgi/generic3/dopamine.htm

Drugs.com

http://www.drugs.com/cdi/dopamine.html

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