Tìm theo
Dobutamine
Các tên gọi khác (10 ) :
  • (+-)-4-(2-((3-(P-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol
  • 3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine
  • 4-{2-[3-(4-hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol
  • DL-Dobutamine
  • Dobutamin
  • Dobutamina
  • Dobutamine
  • Dobutaminum
  • rac-Dobutamine
  • Racemic-dobutamine
Thuốc tim mạch
Thuốc Gốc
Small Molecule
CAS: 34368-04-2
ATC: C01CA07
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C18H23NO3
PTK: 301.3801
A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H23NO3
Phân tử khối
301.3801
Monoisotopic mass
301.167793607
InChI
InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3
InChI Key
InChIKey=JRWZLRBJNMZMFE-UHFFFAOYSA-N
IUPAC Name
4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol
Traditional IUPAC Name
dobutamine
SMILES
CC(CCC1=CC=C(O)C=C1)NCCC1=CC(O)=C(O)C=C1
Độ tan chảy
184-186
Độ hòa tan
1.37e-02 g/l
logP
3.6
logS
-4.3
pKa (strongest acidic)
10.14
pKa (Strongest Basic)
9.27
PSA
72.72 Å2
Refractivity
88.39 m3·mol-1
Polarizability
34.44 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
4
H Bond Donor Count
4
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Dobutamine acts primarily on beta-1 adrenergic receptors, with little effect on beta-2 or alpha receptors. It does not cause the release of endogenous norepinephrine, as does dopamine. Dobutamine is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.
Cơ Chế Tác Dụng : A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output.
Dược Động Học :

▧ Route of Elimination :
In human urine, the major excretion products are the conjugates of dobutamine and 3-O-methyl dobutamine.
▧ Half Life :
2 minutes
Chỉ Định : For inotropic support in the short- term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures
Tương Tác Thuốc :
  • Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect, dobutamine.
  • Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of dobutamine.
  • Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of dobutamine.
  • Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of dobutamine.
  • Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of dobutamine.
  • Entacapone Entacapone increases the effect and toxicity of the sympathomimetic, dobutamine.
  • Guanethidine Dobutamine may decrease the effect of guanethidine.
  • Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of dobutamine.
  • Isocarboxazid Increased arterial pressure
  • Linezolid Possible increase of arterial pressure
  • Methyldopa Increased arterial pressure
  • Midodrine Increased arterial pressure
  • Moclobemide Moclobemide increases the sympathomimetic effect of dobutamine.
  • Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of dobutamine.
  • Phenelzine Increased arterial pressure
  • Rasagiline Increased arterial pressure
  • Reserpine Increased arterial pressure
Liều Lượng & Cách Dùng : Liquid - Intravenous
Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Bayer
    Sản phẩm biệt dược : Dobuject
  • Công ty : Claris
    Sản phẩm biệt dược : Dobusafe
  • Công ty : Sandoz
    Sản phẩm biệt dược : Dobutamin
  • Công ty : Demo
    Sản phẩm biệt dược : Dobutan
  • Công ty : Novell
    Sản phẩm biệt dược : Dobutel
  • Công ty : Meizler
    Sản phẩm biệt dược : Dobutil
  • Công ty : Lilly
    Sản phẩm biệt dược : Dobutrex
  • Công ty : Mylan Seiyaku
    Sản phẩm biệt dược : Dopmin
  • Công ty : Lilly
    Sản phẩm biệt dược : Inotrex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00841
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=36811
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505241
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06967
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D03879
ChemSpider
http://www.chemspider.com/Chemical-Structure.33786.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028971
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/55390-560-90
PharmGKB
http://www.pharmgkb.org/drug/PA449381
Wikipedia
http://en.wikipedia.org/wiki/Dobutamine
RxList
http://www.rxlist.com/cgi/generic3/dobutamine.htm
Drugs.com
http://www.drugs.com/cdi/dobutamine.html
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