Tìm theo
Dihydroxyaluminium
Thuốc Gốc
Small Molecule
CAS: 13682-92-3
CTHH: C2H8AlNO4
PTK: 137.0708
Aluminium monostearate is an organic compound which is a salt of stearic acid and aluminium. It has the molecular formula Al(OH)2C18H35O2. It is also referred to as dihydroxyaluminium or dihydroxy(stearato)aluminium. It is used to form gels in the packaging of pharmaceuticals, and in the preparation of colors for cosmetics. It is usually safe in commercial products, but aluminium may accumulate in the body.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C2H8AlNO4
Phân tử khối
137.0708
Monoisotopic mass
137.02687119
InChI
InChI=1S/C2H5NO2.Al.2H2O/c3-1-2(4)5;;;/h1,3H2,(H,4,5);;2*1H2/q;+1;;/p-1
InChI Key
InChIKey=RBNPZEHAODHBPZ-UHFFFAOYSA-M
IUPAC Name
$l^{1}-alumanyl 2-aminoacetate dihydrate
Traditional IUPAC Name
$l^{1}-alumanyl 2-aminoacetate dihydrate
SMILES
O.O.NCC(=O)O[Al]
logP
-1.85
pKa (Strongest Basic)
7.19
PSA
52.32 Å2
Refractivity
15.08 m3·mol-1
Polarizability
8.34 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : Aluminium monostearate is an organic compound which is a salt of stearic acid and aluminium. It has the molecular formula Al(OH)2C18H35O2. It is also referred to as dihydroxyaluminium or dihydroxy(stearato)aluminium. It is used to form gels in the packaging of pharmaceuticals, and in the preparation of colors for cosmetics. It is usually safe in commercial products, but aluminium may accumulate in the body. Aluminum hydroxide is one component of the antacids recommended in the treatment of stomach ulcers and gastritis. Antacids perform a neutralization reaction, ie. they buffer gastric acid, raising the pH to reduce acidity in the stomach. When gastric hydrochloric acid reaches the nerves in the gasitrointestinal mucosa, they signal pain to the central nervous system. This happens when these nerves are exposed, as in peptic ulcers. The gastric acid may also reach ulcers in the esophagus or the duodenum. Other mechanisms may contribute, such as the effect of aluminum ions inhibiting smooth muscle cell contraction and delaying gastric emptying. Aluminum is known to bind troponin C (a muscle protein) and to interfere with voltage-dependent calcium transport. Aluminum also binds to and inhibits the activity of mitochondrial voltage gated channels (VDAC).
Tương Tác Thuốc :
  • Amprenavir The antiacid decreases the absorption of amprenavir
  • Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir
  • Chloroquine The antiacid decreases the absorption of chloroquine
  • Ciprofloxacin Formation of non-absorbable complexes
  • Clindamycin The aluminium salt decreases the absorption of lincosamides
  • Clodronate Formation of non-absorbable complexes
  • Tetracycline Formation of non-absorbable complexes
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01375
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=18502861
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505934
ChemSpider
http://www.chemspider.com/Chemical-Structure.17615602.html
PharmGKB
http://www.pharmgkb.org/drug/PA164746763
Wikipedia
http://en.wikipedia.org/wiki/Aluminium_monostearate
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