Tìm theo
Dextrothyroxine
Các tên gọi khác (5 ) :
  • D-T4
  • D-thyroxine
  • Dextrothyroxine
  • DT4
  • O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine
hypolipidemic agents
Thuốc Gốc
Small Molecule
CAS: 51-49-0
ATC: C10AX01
CTHH: C15H11I4NO4
PTK: 776.87
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H11I4NO4
Phân tử khối
776.87
Monoisotopic mass
776.686681525
InChI
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1
InChI Key
InChIKey=XUIIKFGFIJCVMT-GFCCVEGCSA-N
IUPAC Name
(2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
Traditional IUPAC Name
dextrothyroxine
SMILES
N[C@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O
Độ tan chảy
235-236 °C
Độ hòa tan
8.98e-03 g/l
logP
4
logS
-4.9
pKa (strongest acidic)
0.27
pKa (Strongest Basic)
9.43
PSA
92.78 Å2
Refractivity
126.79 m3·mol-1
Polarizability
49.31 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
4
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Dược Lực Học : Dextrothyroxine, the dextrorotary isomer of the synthetic thyroxine, is a antihyperlipidemic.
Cơ Chế Tác Dụng : The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem] Dextrothyroxine is a antihyperlipidemic. The mechanism of action is not completely understood, but dextrothyroxine apparently acts in the liver to stimulate formation of low-density lipoprotein (LDL) and, to a much greater extent, to increase catabolism of LDL. This leads to increased excretion of cholesterol and bile acids via the biliary route into the feces, with a resulting reduction in serum cholesterol and LDL. Dextrothyroxine has no significant effect on high-density lipoproteins (HDL). Inherently, it will also bind to thyroid receptors and as it is a prohormone, it will bind as a substrate to iodide peroxidase.
Độc Tính : Symptoms of dextrothyroxine overdose are unknown.
Chỉ Định : Used to lower high cholesterol levels in the blood.
Tương Tác Thuốc :
  • Acenocoumarol The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of acenocoumarol.
  • Anisindione The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of anisindione.
  • Dicoumarol The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of dicumarol.
  • Digoxin The thyroid hormone, dextrothyroxine, decreases the effect of digoxin.
  • Warfarin The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of warfarin.
Liều Lượng & Cách Dùng : Powder, for solution - Intravenous
Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00509
PharmGKB
http://www.pharmgkb.org/drug/PA164752444
Wikipedia
http://en.wikipedia.org/wiki/Dextrothyroxine
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