Tìm theo
Clindamycin
Các tên gọi khác (8 ) :
  • 7-CDL
  • 7(S)-Chloro-7-deoxylincomycin
  • Cleocin (tn)
  • Clindamicina
  • Clindamycin
  • Clindamycine
  • Clindamycinum
  • Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 18323-44-9
ATC: D10AF01, G01AA10, J01FF01
ĐG : Accra Pac Inc.
CTHH: C18H33ClN2O5S
PTK: 424.983
Clindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H33ClN2O5S
Phân tử khối
424.983
Monoisotopic mass
424.179870573
InChI
InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9?,10-,11+,12?,13+,14-,15-,16-,18-/m1/s1
InChI Key
InChIKey=KDLRVYVGXIQJDK-NOWPCOIGSA-N
IUPAC Name
(2S,4R)-N-{2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide
Traditional IUPAC Name
clindamycin
SMILES
CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC(C(C)Cl)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O
Độ tan chảy
142 [HCl salt]
Độ hòa tan
30.6 mg/L
logP
2.16
logS
-2.1
pKa (strongest acidic)
12.16
pKa (Strongest Basic)
7.55
PSA
102.26 Å2
Refractivity
105.72 m3·mol-1
Polarizability
44.49 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
6
H Bond Donor Count
4
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
Cơ Chế Tác Dụng : Clindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration. Systemic/vaginal clindamycin inhibits protein synthesis of bacteria by binding to the 50S ribosomal subunits of the bacteria. Specifically, it binds primarily to the 23s RNA subunit. Topical clindamycin reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes) , an anaerobe found in sebaceous glands and follicles.
Dược Động Học :
▧ Absorption :
Rapidly absorbed after oral administration with peak serum concentrations observed after about 45 minutes. Absorption of an oral dose is virtually complete (90%) and the concomitant intake of food does not appreciably modify the serum concentrations; serum levels have been uniform and predictable from person to person and dose to dose. Clindamycin does not penetrate the blood brain barrier.
▧ Protein binding :
92-94%
▧ Metabolism :
Hepatic
▧ Route of Elimination :
Approximately 10% of the bioactivity is excreted in the urine and 3.6% in the feces; the remainder is excreted as bioinactive metabolites.
▧ Half Life :
2.4 hours
Độc Tính : Adverse effects include nausea (may be dose-limiting), diarrhea, pseudomembranous colitis, allergic reactions, hepatoxicity, transient neutropenia and eosinophilia and agranulocytosis. Pseudomembranous colitis occurs in 0.01 - 10% of patients and occurs more commonly than with other antibiotics. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Chỉ Định : For the treatment of serious infections caused by susceptible anaerobic bacteria, including Bacteroides spp., Peptostreptococcus, anaerobic streptococci, Clostridium spp., and microaerophilic streptococci. May be useful in polymicrobic infections such as intra-abdominal or pelvic infections, osteomyelitis, diabetic foot ulcers, aspiration pneumonia and dental infections. May also be used to treat MSSA and respiratory infections caused by S. pneumoniae and S. pyogenes in patients who are intolerant to other indicated antibiotics or who are infected with resistant organism. May be used vaginally to treat vaginosis caused by Gardnerella vaginosa. Clindamycin reduces the toxin producing effects of S. aureus and S. pyogenes and as such, may be particularly useful for treating necrotizing fasciitis. May be used topically to treat acne.
Tương Tác Thuốc :
  • Aluminium The aluminium salt decreases the absorption of lincosamides
  • Atracurium The agent increases the effect of muscle relaxant
  • Attapulgite The aluminium salt decreases the absorption of lincosamides
  • Cyclosporine Clindamycin may decrease the therapeutic effect of cyclosporine.
  • Dihydroxyaluminium The aluminium salt decreases the absorption of lincosamides
  • Doxacurium chloride The agent increases the effect of muscle relaxant
  • Kaolin The aluminium salt decreases the absorption of lincosamides
  • Metocurine The agent increases the effect of muscle relaxant
  • Mivacurium The agent increases the effect of muscle relaxant
  • Pancuronium The agent increases the effect of muscle relaxant
  • Pipecuronium The agent increases the effect of muscle relaxant
  • Rocuronium The agent increases the effect of muscle relaxant
  • Succinylcholine The agent increases the effect of muscle relaxant
  • Tubocurarine The agent increases the effect of muscle relaxant
  • Vecuronium The agent increases the effect of muscle relaxant
Liều Lượng & Cách Dùng : Capsule - Oral
Cream - Intravaginal
Cream - Topical
Liquid - Intramuscular
Liquid - Intravenous
Powder, for solution - Oral
Solution - Intravenous
Solution - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Pfizer
    Sản phẩm biệt dược : Cleocin
  • Công ty : Paddock
    Sản phẩm biệt dược : Clinda-Derm
  • Công ty :
    Sản phẩm biệt dược : Clindagel
  • Công ty :
    Sản phẩm biệt dược : Clindamax
  • Công ty :
    Sản phẩm biệt dược : Clindesse
  • Công ty : Perrigo
    Sản phẩm biệt dược : Clindets
  • Công ty : Hayat
    Sản phẩm biệt dược : Clinimycin
  • Công ty : Pfizer
    Sản phẩm biệt dược : Dalacin C
  • Công ty : Pfizer
    Sản phẩm biệt dược : Dalacin T Topical Solution
  • Công ty : Stiefel
    Sản phẩm biệt dược : Evoclin
  • Công ty : Crawford
    Sản phẩm biệt dược : Zindaclin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01190
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=29029
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506073
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06914
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00277
ChemSpider
http://www.chemspider.com/Chemical-Structure.27005.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0009-0331-02
PharmGKB
http://www.pharmgkb.org/drug/PA449035
Wikipedia
http://en.wikipedia.org/wiki/Clindamycin
RxList
http://www.rxlist.com/cgi/generic2/clindam.htm
Drugs.com
http://www.drugs.com/clindamycin.html
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