Tìm theo
Cinolazepam
Các tên gọi khác (4 ) :
  • 1-(2-Cyanoethyl)-7-chloro-3-hydroxy-5-(2'-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • 7-chloro-5-(2-Fluorophenyl)-2,3-dihydro-3-hydroxy-2-oxo-1H-1,4-benzodiazepine-1-propanenitrile
  • 7-chloro-5-(O-Fluorophenyl)-2,3-dihydro-3-hydroxy-2-oxo-1H-1,4-benzodiazepine-1-propionitrile
  • Cinolazepamum
Thuốc an thần
Thuốc Gốc
Small Molecule
CAS: 75696-02-5
ATC: N05CD13
CTHH: C18H13ClFN3O2
PTK: 357.766
Cinolazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Cinolazepam is not approved for sale in the United States or Canada.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H13ClFN3O2
Phân tử khối
357.766
Monoisotopic mass
357.068032587
InChI
InChI=1S/C18H13ClFN3O2/c19-11-6-7-15-13(10-11)16(12-4-1-2-5-14(12)20)22-17(24)18(25)23(15)9-3-8-21/h1-2,4-7,10,17,24H,3,9H2
InChI Key
InChIKey=XAXMYHMKTCNRRZ-UHFFFAOYSA-N
IUPAC Name
3-[7-chloro-5-(2-fluorophenyl)-3-hydroxy-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-1-yl]propanenitrile
Traditional IUPAC Name
cinolazepam
SMILES
OC1N=C(C2=CC=CC=C2F)C2=C(C=CC(Cl)=C2)N(CCC#N)C1=O
Độ hòa tan
1.20e-02 g/l
logP
2.7
logS
-4.5
pKa (strongest acidic)
10.68
pKa (Strongest Basic)
-2.5
PSA
76.69 Å2
Refractivity
90.99 m3·mol-1
Polarizability
34.12 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
4
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Cinolazepam is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Cinolazepam is not approved for sale in the United States or Canada.
Cơ Chế Tác Dụng : Cinolazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Cinolazepam is not approved for sale in the United States or Canada. Cinolazepam binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Dược Động Học :
▧ Absorption :
Bioavailability following oral administration is 90-100%.
▧ Metabolism :
Hepatic.
▧ Half Life :
9 hours
Độc Tính : The onset of impairment of consciousness is relatively rapid in benzodiazepine poisoning. Onset is more rapid following larger doses and with agents of shorter duration of action. The most common and initial symptom is somnolence. This may progress to coma Grade I or Grade II following very large ingestions.
Chỉ Định : For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Gerodorm
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01594
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3033621
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508803
ChemSpider
http://www.chemspider.com/Chemical-Structure.2298251.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748034
Wikipedia
http://en.wikipedia.org/wiki/Cinolazepam
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