Tìm theo
Cefotetan
Các tên gọi khác (2) :
  • (6R,7S)-7-(4-(Carbamoylcarboxymethylene)-1,3-dithiethane-2-carboxamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5- yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2- carboxylic acid
  • Cefotetanum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 69712-56-7
ATC: J01DC05
ĐG : APP Pharmaceuticals , http://www.apppharma.com
CTHH: C17H17N7O8S4
PTK: 575.619
A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H17N7O8S4
Phân tử khối
575.619
Monoisotopic mass
575.002143315
InChI
InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1
InChI Key
InChIKey=SRZNHPXWXCNNDU-IXOPCIAXSA-N
IUPAC Name
(6R,7S)-7-{4-[carbamoyl(carboxy)methylidene]-1,3-dithietane-2-amido}-7-methoxy-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefotetan
SMILES
[H][C@]12SCC(CSC3=NN=NN3C)=C(N1C(=O)[C@]2(NC(=O)C1SC(S1)=C(C(N)=O)C(O)=O)OC)C(O)=O
Độ hòa tan
5.21e-01 g/l
logP
-0.38
logS
-3
pKa (strongest acidic)
3.23
pKa (Strongest Basic)
-1.3
PSA
219.93 Å2
Refractivity
153.55 m3·mol-1
Polarizability
51.81 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
11
H Bond Donor Count
4
Physiological Charge
-2
Number of Rings
4
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Cefotetan is a semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Cơ Chế Tác Dụng : A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. [PubChem] The bactericidal action of cefotetan results from inhibition of cell wall synthesis by binding and inhibiting the bacterial penicillin binding proteins which help in the cell wall biosynthesis.
Dược Động Học :

▧ Volume of Distribution :
* 10.4 L [elderly patients (greater than 65 years) with normal renal function] * 10.3 L [healthy volunteers (aged 25 to 28 years)]
▧ Protein binding :
Cefotetan is 88% plasma protein bound.
▧ Metabolism :
No active metabolites of cefotetan have been detected; however, small amounts (less than 7%) of cefotetan in plasma and urine may be converted to its tautomer, which has antimicrobial activity similar to the parent drug.
▧ Route of Elimination :
No active metabolites of cefotetan have been detected; however, small amounts (less than 7%) of cefotetan in plasma and urine may be converted to its tautomer, which has antimicrobial activity similar to the parent drug. In normal patients, from 51% to 81% of an administered dose of Cefotetan is excreted unchanged by the kidneys over a 24 hour period, which results in high and prolonged urinary concentrations.
▧ Half Life :
In volunteers with reduced renal function, the plasma half-life of cefotetan is prolonged
▧ Clearance :
* 1.8 +/- 0.1 L/h [elderly patients with normal renal function (.65 years)] * 1.8 +/- 0.3 L/h [healthy volunteers (aged 25 to 28 years)]
Chỉ Định : For prophylaxis and treatment of bacterial infections.
Tương Tác Thuốc :
  • Acenocoumarol The cephalosporin, cefotetan, may increase the anticoagulant effect of acenocoumarol.
  • Amikacin Increased risk of nephrotoxicity
  • Anisindione The cephalosporin, cefotetan, may increase the anticoagulant effect of anisindione.
  • Dicoumarol The cephalosporin, cefotetan, may increase the anticoagulant effect of dicumarol.
  • Gentamicin Increased risk of nephrotoxicity
  • Kanamycin Increased risk of nephrotoxicity
  • Neomycin Increased risk of nephrotoxicity
  • Netilmicin Increased risk of nephrotoxicity
  • Probenecid Probenecid may increase the serum level of cefotetan.
  • Streptomycin Increased risk of nephrotoxicity
  • Tobramycin Increased risk of nephrotoxicity
  • Warfarin The cephalosporin, cefotetan, may increase the anticoagulant effect of warfarin.
Liều Lượng & Cách Dùng : Injection, solution - Intramuscular
Injection, solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Cefotan
  • Công ty :
    Sản phẩm biệt dược : Yamatetan
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01330
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06886
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00260
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0310-0376-31
PharmGKB
http://www.pharmgkb.org/drug/PA164784033
Wikipedia
http://en.wikipedia.org/wiki/Cefotetan
RxList
http://www.rxlist.com/cgi/generic/cefotet.htm
Drugs.com
http://www.drugs.com/cdi/cefotetan.html
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