Tìm theo
Calcium carbonate
Các tên gọi khác (11 ) :
  • CaCO3
  • Calcium carbonate
  • Calcium carbonate (1:1)
  • Calciumcarbonat
  • Carbonate de calcium
  • Carbonato de calcio
  • Carbonic acid calcium salt (1:1)
  • e 170
  • Kalziumkarbonat
  • Kohlensaurer kalk
  • Precipitated calcium carbonate
antacids
Thuốc Gốc
Small Molecule
Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.
Dược Lực Học : Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml. When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body.
Cơ Chế Tác Dụng : Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia. Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).
Dược Động Học :
▧ Absorption :
Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.
▧ Volume of Distribution :
Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.
▧ Protein binding :
Calcium acts as a co-factor to numerous enzymes.
▧ Metabolism :
None.
▧ Route of Elimination :
Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.
Chỉ Định : For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.
Tương Tác Thuốc :
  • Calcium Acetate Calcium salts may enhance the adverse/toxic effect of calcium acetate. Concurrent use of other calcium salts with calcium acetate should be avoided when possible. This combination is particularly dangerous in patients with other risk factors for hypercalcemia, such as those with end-stage renal disease.
  • Calcium Chloride Calcium salts may enhance the adverse/toxic effect of calcium chloride. Concurrent use of other calcium salts with calcium acetate should be avoided when possible. This combination is particularly dangerous in patients with other risk factors for hypercalcemia, such as those with end-stage renal disease.
  • Eltrombopag Decreases levels of eltrombopag by GI absorption inhibition.
  • Itraconazole The antacid, calcium carbonate, may decrease the effect of itraconazole by decreasing its absorption.
Liều Lượng & Cách Dùng : Suspension - Oral - 400 mg/5 ml
Tablet - Oral - 1.25 g
Tablet - Oral - 500 mg
Tablet, chewable - Oral - 400 mg
Tablet, chewable - Oral - 500 mg
Tablet, chewable - Oral - 650 mg
Tablet, chewable - Oral - 750 mg
Tablet, chewable - Oral - 850 mg
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06724
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