Tìm theo
Bismuth Subsalicylate
Các tên gọi khác (7 ) :
  • 2-Hydroxy-benzo[1,3,2]dioxabismin-4-one
  • Basic bismuth salicylate
  • Bismuth oxide salicylate
  • Bismuth oxysalicylate
  • Bismuth subsalicylate
  • pink bismuth
  • Wismutsubsalicylat
antidiarrheals
Thuốc Gốc
Small Molecule
CAS: 14882-18-9
ATC: A02BX05, A02BX12
ĐG : Amend
CTHH: C7H5BiO4
PTK: 362.0926
Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. It is also the main ingredient of Kaopectate. It displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C7H5BiO4
Phân tử khối
362.0926
Monoisotopic mass
361.999166889
InChI
InChI=1S/C7H6O3.Bi.H2O/c8-6-4-2-1-3-5(6)7(9)10;;/h1-4,8H,(H,9,10);;1H2/q;+3;/p-3
InChI Key
InChIKey=ZREIPSZUJIFJNP-UHFFFAOYSA-K
IUPAC Name
2-hydroxy-2H,4H-benzo[d]1,3-dioxa-2-bismacyclohexan-4-one
Traditional IUPAC Name
bismuth subsalicylate
SMILES
O[Bi]1OC(=O)C2=CC=CC=C2O1
Độ hòa tan
5.97e+01 g/l
logP
1.11
logS
-0.78
pKa (strongest acidic)
14.3
pKa (Strongest Basic)
-3.1
PSA
55.76 Å2
Refractivity
35.72 m3·mol-1
Polarizability
15.67 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : Bismuth subsalicylate displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic. It can also cause a black tongue and black stools in some users of the drug, when it combines with trace amounts of sulfur in their saliva and gastrointestinal tract. This discoloration is temporary and harmless.
Cơ Chế Tác Dụng : Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. It is also the main ingredient of Kaopectate. It displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic. As an antidiarrheal, the exact mechanism has not been determined. Bismuth subsalicylate may exert its antidiarrheal action not only by stimulating absorption of fluid and electrolytes across the intestinal wall (antisecretory action) but also, when hydrolyzed to salicylic acid, by inhibiting synthesis of a prostaglandin responsible for intestinal inflammation and hypermotility. In addition, bismuth subsalicylate binds toxins produced by Escherichia coli. Both bismuth subsalicylate and the intestinal reaction products, bismuth oxychloride and bismuth hydroxide, are believed to have bactericidal action. As an antacid, bismuth has weak antacid properties.
Dược Động Học :
▧ Absorption :
Following oral administration, absorption of the salicylate component from the small intestine is generally rapid and complete (>90%).
▧ Metabolism :
Based on in vitro dissociation data and in vivo animal data, bismuth subsalicylate is believed to be largely hydrolyzed in the stomach to bismuth oxychloride and salicylic acid. In the small intestine, nondissociated bismuth subsalicylate reacts with other anions (bicarbonate and phosphate) to form insoluble bismuth salts. In the colon, nondissociated bismuth subsalicylate and other bismuth salts react with hydrogen sulfide to produce bismuth sulfide, a highly insoluble black salt responsible for the darkening of the stools.
Chỉ Định : Used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
Tương Tác Thuốc :
  • Acetazolamide The salicylate, bismuth subsalicylate, at high dose increases the effect of the carbonic anhydrase inhibitor, acetazolamide.
  • Amprenavir The antiacid decreases the absorption of amprenavir
  • Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir
  • Betamethasone The corticosteroid, betamethasone, may decrease the effect of the salicylate, bismuth subsalicylate.
  • Fludrocortisone The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, bismuth subsalicylate.
  • Gliclazide The salicylate, bismuth subsalicylate, increases the effect of the sulfonylurea, gliclazide.
  • Glyburide The salicylate, bismuth subsalicylate, increases the effect of the sulfonylurea, glibenclamide.
  • Hydrocortisone The corticosteroid, hydrocortisone, may decrease the effect of the salicylate, bismuth subsalicylate.
  • Methazolamide The salicylate, bismuth subsalicylate, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
  • Methotrexate The salicylate, bismuth subsalicylate, increases the effect and toxicity of methotrexate.
  • Minocycline Formation of non-absorbable complexes
  • Prednisolone The corticosteroid, prednisolone, may decrease the effect of the salicylate, bismuth subsalicylate.
  • Prednisone The corticosteroid, prednisone, may decrease the effect of the salicylate, bismuth subsalicylate.
  • Probenecid The salicylate, bismuth subsalicylate, decreases the uricosuric effect of probenecid.
  • Tetracycline Formation of non-absorbable complexes
  • Triamcinolone The corticosteroid, triamcinolone, may decrease the effect of the salicylate, bismuth subsalicylate.
Liều Lượng & Cách Dùng : Dressing - Topical
Liquid - Oral
Liquid - Sublingual
Solution / drops - Oral
Suppository - Rectal
Suspension - Oral
Suspension - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Bismatrol
  • Công ty :
    Sản phẩm biệt dược : Maalox Multi-Action
  • Công ty :
    Sản phẩm biệt dược : Pepto-bismol
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01294
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=16682734
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507128
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07870
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00728
ChemSpider
http://www.chemspider.com/Chemical-Structure.17615374.html
PharmGKB
http://www.pharmgkb.org/drug/PA164774805
Wikipedia
http://en.wikipedia.org/wiki/Bismuth_subsalicylate
RxList
http://www.rxlist.com/cgi/generic/pylera.htm
Drugs.com
http://www.drugs.com/cdi/bismuth-subsalicylate.html
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