Tìm theo
Aluminum hydroxide
Các tên gọi khác (3) :
  • Al(OH)3
  • Aluminiumhydroxid
  • Aluminum hydroxide
Thuốc kháng acid, Thuốc chống loét khác tác dụng trên đường tiêu hóa
Thuốc Gốc
Small Molecule
CTHH: AlH3O3
PTK: 78.0036
Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
AlH3O3
Phân tử khối
78.0036
Monoisotopic mass
77.989757403
InChI
InChI=1S/Al.3H2O/h;3*1H2/q+3;;;/p-3
InChI Key
InChIKey=WNROFYMDJYEPJX-UHFFFAOYSA-K
IUPAC Name
aluminium(3+) ion trioxidanide
Traditional IUPAC Name
aluminium(3+) trihydroxide
SMILES
[OH-].[OH-].[OH-].[Al+3]
logP
1.45
pKa (strongest acidic)
15.7
pKa (Strongest Basic)
-1.8
Polarizability
1.78 Å3
Polar Surface Area (PSA)
0
Refractivity
0
Rotatable Bond Count
0
H Bond Acceptor Count
0
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion.
Cơ Chế Tác Dụng : Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.
Dược Động Học :
▧ Absorption :
Approximately 17-30% of the aluminum chloride formed is absorbed.
▧ Metabolism :
Not metabolized.
▧ Route of Elimination :
Absorbed aluminum chloride is rapidly eliminated by the kidneys in patients with normal renal function.
Chỉ Định : For relief of heartburn and acid indigestion.
Tương Tác Thuốc :
  • Calcipotriol Vitamin D Analogs may increase the serum concentration of Aluminum Hydroxide. Specifically, the absorption of aluminum may be increased, leading to increased serum aluminum concentrations. Avoid chronic and/or excessive use of aluminum and aluminum-containing products in patients who are also taking vitamin D analogs. Any patients consuming such a combination should be monitored closely for aluminum status and signs/symptoms of aluminum-related toxicities.
  • Cholecalciferol Vitamin D analogs such as cholecalciferol may increase the serum concentration of aluminum hydroxide. Specifically, the absorption of aluminum may be increased, leading to increased serum aluminum concentrations. Avoid chronic and/or excessive use of aluminum and aluminum-containing products in patients who are also taking vitamin D analogs. Any patients consuming such a combination should be monitored closely for aluminum status and signs/symptoms of aluminum-related toxicities.
  • Deferiprone Deferiprone may decrease gastrointestinal absorption by chelating to other ions. Interaction is significant so monitor closely.
  • Eltrombopag Decreases levels of eltrombopag by GI absorption inhibition.
Liều Lượng & Cách Dùng : Capsule - Oral - 475 mg
Suspension - Oral - 320 mg/5 ml
Suspension - Oral - 600 mg/5 ml
Tablet - Oral - 300 mg
Tablet, film coated - Oral - 600 mg
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : J&J-Merck
    Sản phẩm biệt dược : AlternaGel
  • Công ty : 3M
    Sản phẩm biệt dược : Alu-Cap
  • Công ty : Wyeth
    Sản phẩm biệt dược : Amphojel
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06723
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