Tìm theo
Altretamine
Các tên gọi khác (10 ) :
  • 2,4,6-Tris(dimethylamino)-1,3,5-triazine
  • 2,4,6-Tris(dimethylamino)-S-triazine
  • Altretamin
  • Altretamina
  • Altrétamine
  • Altretaminum
  • Hexalen
  • Hexamethylmelamine
  • Hexastat
  • HMM
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 645-05-6
ATC: L01XX03
ĐG : AAIPharma Inc. , http://www.aaipharma.com
CTHH: C9H18N6
PTK: 210.2794
An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H18N6
Phân tử khối
210.2794
Monoisotopic mass
210.159294606
InChI
InChI=1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3
InChI Key
InChIKey=UUVWYPNAQBNQJQ-UHFFFAOYSA-N
IUPAC Name
2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine
Traditional IUPAC Name
altretamine
SMILES
CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C
Độ tan chảy
168
Độ hòa tan
91 mg/L (at 25 °C)
logP
2.73
logS
-1.8
pKa (Strongest Basic)
7.75
PSA
48.39 Å2
Refractivity
65.65 m3·mol-1
Polarizability
23.7 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
6
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.
Cơ Chế Tác Dụng : An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. [PubChem] The precise mechanism by which altretamine exerts its cytotoxic effect is unknown although it is classified as an alkylating anti-neoplastic agent. Through this mechanism, the drug is metabolized into alkylating agents by N-demethylation. These alkylating species consequently damage tumor cells.
Dược Động Học :

▧ Protein binding :
94%
▧ Route of Elimination :
Human urinary metabolites were Ndemethylated homologues of altretamine with <1% unmetabolized altretamine excreted at 24 hours.
▧ Half Life :
4.7-10.2 hours
Chỉ Định : For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Hexalen 50 mg capsule
    Giá bán buôn : USD >12.03
    Đơn vị tính : capsule
Nhà Sản Xuất
  • Công ty : Eisai
    Sản phẩm biệt dược : Hexalen
  • Công ty : ProStrakan
    Sản phẩm biệt dược : Hexastat
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00488
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2123
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505760
ChemSpider
http://www.chemspider.com/Chemical-Structure.2038.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/58063-001-70
PharmGKB
http://www.pharmgkb.org/drug/PA164743136
Wikipedia
http://en.wikipedia.org/wiki/Altretamine
RxList
http://www.rxlist.com/cgi/generic/altretamine.htm
Drugs.com
http://www.drugs.com/cdi/altretamine.html
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