Dược Động Học :
▧ Absorption :
The oral bioavailability is 10% to 20%, and decreases with increasing dose. Food does not affect the absorption of acyclovir. The following are the pharmacokinetic parameters for 50 mg buccal tablet, Sitavig, in the saliva:
AUC 0 - 24 hours = 2900±2400 mcg.h/mL;
Cmax = 440±241 mcg/mL;
Tmax = 7.95 ± 4.08 hours.
▧ Protein binding :
▧ Metabolism :
Hepatic, Acyclovir is metabolized to 9-[(carboxymethoxy)methyl]guanine (CMMG) and 8 hydroxy-acyclovir (8-OH-ACV) by oxidation and hydroxylation. It is suggested in studies that acyclovir is first metabolized to acyclovir aldehyde by alcohol dehydrogenase and then converted to CMMG. The build up of acyclovir aldehyde may be the cause of acyclovir-induced nephrotoxicity in the absence of crystalluria.
▧ Route of Elimination :
Primarily excreted unchanged by the kidneys via active tubular secretion.
▧ Half Life :