Tìm theo
Zomepirac
Các tên gọi khác (2) :
  • 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid
  • Zomepiracum
anti inflammatory agents non steroidal
Thuốc Gốc
Small Molecule
CAS: 33369-31-2
ATC: M01AB04
CTHH: C15H14ClNO3
PTK: 291.73
Zomepirac, formerly marketed as Zomax tablets, was associated with fatal and near-fatal anaphylactoid reactions. The manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H14ClNO3
Phân tử khối
291.73
Monoisotopic mass
291.066221026
InChI
InChI=1S/C15H14ClNO3/c1-9-7-12(8-13(18)19)17(2)14(9)15(20)10-3-5-11(16)6-4-10/h3-7H,8H2,1-2H3,(H,18,19)
InChI Key
InChIKey=ZXVNMYWKKDOREA-UHFFFAOYSA-N
IUPAC Name
2-{5-[(4-chlorophenyl)carbonyl]-1,4-dimethyl-1H-pyrrol-2-yl}acetic acid
Traditional IUPAC Name
zomepirac
SMILES
CN1C(CC(O)=O)=CC(C)=C1C(=O)C1=CC=C(Cl)C=C1
Độ tan chảy
178.5 °C
Độ hòa tan
2.60e-02 g/l
logP
3.33
logS
-4
pKa (strongest acidic)
3.86
pKa (Strongest Basic)
-7.8
PSA
59.3 Å2
Refractivity
77.2 m3·mol-1
Polarizability
29.68 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Chỉ Định : Zomepirac was indicated for the management of mild to severe pain.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04828
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5733
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504549
ChemSpider
http://www.chemspider.com/Chemical-Structure.5531.html
Wikipedia
http://en.wikipedia.org/wiki/Zomepirac
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