Tìm theo
Xylometazoline
Các tên gọi khác (2) :
  • Balminil
  • Xylomethazoline
Thuốc dùng điều trị mắt, tai mũi họng
Thuốc Gốc
Small Molecule
CAS: 526-36-3
ATC: R01AB06, R01AA07, S01GA03
CTHH: C16H24N2
PTK: 244.3752
A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways. It binds alpha-adrenergic receptors to activate the adrenal system which causes systemic vasoconstriction, thereby easing nasal congestion.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H24N2
Phân tử khối
244.3752
Monoisotopic mass
244.193948778
InChI
InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18)
InChI Key
InChIKey=HUCJFAOMUPXHDK-UHFFFAOYSA-N
IUPAC Name
2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
Traditional IUPAC Name
xylometazoline
SMILES
CC1=CC(=CC(C)=C1CC1=NCCN1)C(C)(C)C
Độ tan chảy
132 °C
Độ hòa tan
8.93e-03 g/l
logP
3.2
logS
-4.4
pKa (Strongest Basic)
10.29
PSA
24.39 Å2
Refractivity
77.82 m3·mol-1
Polarizability
29.85 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Xylometazoline is a direct acting sympathomimetic adrenergic alpha-agonist used to induce systemic vasoconstriction, thereby decreasing nasal congestion. The sympathomimetic action of xylometazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (8-12 hours) decongesting effect.
Cơ Chế Tác Dụng : A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways. It binds alpha-adrenergic receptors to activate the adrenal system which causes systemic vasoconstriction, thereby easing nasal congestion. Xylometazoline is a direct acting sympathomimetic drug, which acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa. This activates the adrenal system to yield systemic vasoconstrction. In producing vasoconstriction, the result is a decrease in blood flow in the nasal passages and consequently decreased nasal congestion.
Chỉ Định : It is used for treating nasal congestion and minor inflammation due to allergies or colds.
Liều Lượng & Cách Dùng : Spray - Nasal
Suspension / drops - Nasal
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Otriven
  • Công ty :
    Sản phẩm biệt dược : Otrivin
  • Công ty :
    Sản phẩm biệt dược : Otrivine
  • Công ty :
    Sản phẩm biệt dược : Otrix
  • Công ty :
    Sản phẩm biệt dược : Xylomet
  • Công ty : Intas
    Sản phẩm biệt dược : Xylostar
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06694
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5709
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443248
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07913
ChemSpider
http://www.chemspider.com/Chemical-Structure.5507.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50027068
PharmGKB
http://www.pharmgkb.org/drug/PA165958368
Wikipedia
http://en.wikipedia.org/wiki/Xylometazoline
RxList
http://nosesprays.info/result.php?Keywords=Nasal%20Spray
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