Tìm theo
XOMA 052
Thuốc Gốc
Biotech
XOMA 052 is a potent anti-inflammatory monoclonal antibody targeting IL-1b and is being developed as a modulator of cytokine imbalance in IL-1 mediated disease states. It has a very high binding affinity of 300fM and blocks the activation of IL-1 receptors. XOMA 052 is also an IgG2 isotype, which reduces the possibility of antibody dependent cellular cytotoxicity. Blocking IL-1β with XOMA 052 offers a novel approach to the treatment and control of Type 2 diabetes.
Dược Lực Học : In diabetes, insulin production progressively deteriorates over time, partly because of IL-1b mediated beta cell destruction. IL-1b inhibits the function and promotes apoptosis (programmed cell death) of pancreatic beta cells, thus impairing beta cell proliferation, reducing insulin secretion, and continuing this destructive cycle. Proof of concept in patients with Type 2 diabetes has been demonstrated by blocking the IL-1 pathway. Blocking IL-1β with XOMA 052 offers a novel approach to the treatment and control of Type 2 diabetes.
Cơ Chế Tác Dụng : XOMA 052 is a potent anti-inflammatory monoclonal antibody targeting IL-1b and is being developed as a modulator of cytokine imbalance in IL-1 mediated disease states. It has a very high binding affinity of 300fM and blocks the activation of IL-1 receptors. XOMA 052 is also an IgG2 isotype, which reduces the possibility of antibody dependent cellular cytotoxicity. Blocking IL-1β with XOMA 052 offers a novel approach to the treatment and control of Type 2 diabetes. There is evidence that blocking the IL-1 pathway has improved the control of blood glucose. In the presence of high blood glucose, IL-1 beta concentration in the pancreas increases. This increase in IL-1 beta is toxic to the insulin-producing pancreatic islet cells. Death of pancreatic islet cells reduces the production of insulin, contributing to a loss of control of blood glucose levels. Eventually this destructive cycle leads to Type 2 diabetic patients requiring insulin therapy to compensate for their inability to produce insulin. Blocking IL-1 beta may improve insulin production by breaking this cycle and preserving pancreatic islet cells.
Chỉ Định : Investigated for use/treatment in diabetes mellitus type 2.
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drugbank
http://www.drugbank.ca/drugs/DB06062
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