XL418

Thuốc Gốc

Small Molecule

XL418 is a novel anticancer compound.

Cơ Chế Tác Dụng : XL418 is a novel anticancer compound. XL418 is a small molecule that inhibits the activity of protein kinase B (PKB or AKT) and S6 Kinase (S6K), which act downstream of phosphoinosotide-3 kinase (PI3K). Activation of these kinases is a frequent event in human tumors, promoting cell growth, survival, and resistance to chemotherapy and radiotherapy. Inactivation of the pathway through inhibition of AKT is expected to induce apoptosis (programmed cell death) in tumor cells. AKT inhibitors may also sensitize tumor cells to a wide range of chemotherapy.

Dược Động Học :

▧ Protein binding :
XL418 is an inhibitor of protein kinase B (PKB or AKT) and S6 Kinase (S6K), key components of the phosphoinosotide-3 kinase (PI3K) signaling pathway.

Chỉ Định : Cancer

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB05204

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