Tìm theo
WX-G250
Thuốc Gốc
Small Molecule
WX-G250 is a monoclonal chimeric (mouse/human) antibody directed against carbonic anhydrase IX, an antigen expressed in 95% of clear cell renal cell carcinomas (RCC).
Cơ Chế Tác Dụng : WX-G250 is a monoclonal chimeric (mouse/human) antibody directed against carbonic anhydrase IX, an antigen expressed in 95% of clear cell renal cell carcinomas (RCC). Mechanism of action of WX-G250 is antibody dependent cellular cytotoxicity (ADCC). As a monotherapy in metastatic renal cell carcinomas(RCC),WX-G250 demonstrated minimal clinical activity with a 3% partial response rate and a median survival of 16 months. In vitro data suggest that the number of activated ADCC effector cells can be upregulated by low dose interleukin 2 (IL2) administered in a pulsatile fashion.
Chỉ Định : Investigated for use/treatment in gall bladder cancer and renal cell carcinoma.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Rencarex
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05304
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