Tìm theo
Virginiamycin M1
Các tên gọi khác (4 ) :
  • Mikamycin A
  • Ostreogrycin A
  • Pristinamycin IIA
  • Streptogramin A
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 21411-53-0
ATC: J01FG01
CTHH: C28H35N3O7
PTK: 525.5934
Pristinamycin IIA is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics and one component of pristinamycin (the other being pristinamycin IA). It is produced by Streptomyces graminofaciens and other bacteria.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C28H35N3O7
Phân tử khối
525.5934
Monoisotopic mass
525.247500489
InChI
InChI=1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5+,10-9+,18-13+/t19-,20-,26-/m1/s1
InChI Key
InChIKey=DAIKHDNSXMZDCU-FQTGFAPKSA-N
IUPAC Name
(10R,11R,21S)-21-hydroxy-11,19-dimethyl-10-(propan-2-yl)-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.0^{3,7}]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone
Traditional IUPAC Name
(10R,11R,21S)-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.0^{3,7}]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone
SMILES
CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)C2=COC(=N2)CC(=O)C[C@H](O)\C=C(/C)\C=C\CNC(=O)\C=C\[C@H]1C
Độ hòa tan
Poorly soluble in water
logP
2.38
logS
-3.9
pKa (strongest acidic)
11.38
pKa (Strongest Basic)
2.19
PSA
139.04 Å2
Refractivity
144.17 m3·mol-1
Polarizability
55.74 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
6
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Cơ Chế Tác Dụng : Pristinamycin IIA is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics and one component of pristinamycin (the other being pristinamycin IA). It is produced by Streptomyces graminofaciens and other bacteria. Virginiamycin M1 is a macrocyclic lactone antibiotic that acts syngeristically with the structurally unrelated cyclic depsipeptides more commonly known as the virginiamycins B (ostreogrycin B or streptogramin B) and S to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Virginiamycin M1 has proven to be highly active against Gram positive bacteria, particularly methicillin-resistant S. aureus.
Chỉ Định : For the treatment of bacterial infections.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01669
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11299
Wikipedia
http://en.wikipedia.org/wiki/Pristinamycin_IIA
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