Tìm theo
Vasopressin
Các tên gọi khác (5 ) :
  • ADH
  • Antidiuretic hormone
  • Arginine vasopressin
  • Argipressin
  • AVP
antidiuretic agents
Thuốc Gốc
Biotech
CAS: 11000-17-2
ATC: H01BA01
ĐG : American Regent , http://www.americanregent.com
CTHH: C43H67N15O12S2
PTK: 1050.2150
Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C43H67N15O12S2
Phân tử khối
1050.2150
Độ hòa tan
Soluble
Độ kỵ nước
-4.9
Dược Lực Học : Vasopressin is an antidiuretic hormone indicated for the prevention and treatment of postoperative abdominal distention, in abdominal roentgenography to dispel interfering gas shadows, and in diabetes insipidus. Vasopressin can cause contraction of smooth muscle of the gastrointestinal tract and of all parts of the vascular bed, especially the capillaries, small arterioles and venules. It has less effect on the smooth musculature of the large veins. Vasopressin may also be used to control bleeding in some forms of von Willebrand disease and to treat extreme cases of bed wetting in children. It may also play a role in memory formation although the mechanism is unknown.
Cơ Chế Tác Dụng : Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of vasopressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
Dược Động Học :

▧ Protein binding :
1%
▧ Metabolism :
The majority of a dose of vasopressin is metabolized and rapidly destroyed in the liver and kidneys.
▧ Half Life :
10-20 minutes
Chỉ Định : For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
Liều Lượng & Cách Dùng : Liquid - Intramuscular
Solution - Intramuscular
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Pitressin
  • Công ty :
    Sản phẩm biệt dược : Pressyn
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00067
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00840
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00101
PharmGKB
http://www.pharmgkb.org/drug/PA451858
Wikipedia
http://en.wikipedia.org/wiki/Vasopressin
RxList
http://www.rxlist.com/cgi/generic3/vasopressin.htm
Drugs.com
http://www.drugs.com/mtm/vasopressin.html
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