Tìm theo
Urokinase
Các tên gọi khác (3) :
  • U-plasminogen activator
  • uPA
  • Urokinase-type plasminogen activator precursor
Thuốc chống huyết khối
Thuốc Gốc
Biotech
CAS: 9039-53-6
ATC: B01AD04
ĐG : Hospira Inc. , http://www.hospira.com
CTHH: C1376H2145N383O406S18
PTK: 31126.5000
Low molecular weight form of human urokinase, that consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Recombinant urokinase plasminogen activator
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C1376H2145N383O406S18
Phân tử khối
31126.5000
Độ tan chảy
76 °C at pH 4.5
Độ kỵ nước
-0.466
Điểm đẳng điện tích
8.66
Dược Lực Học : Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.
Cơ Chế Tác Dụng : Low molecular weight form of human urokinase, that consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Recombinant urokinase plasminogen activator Urokinase acts on the endogenous fibrinolytic system. It cleaves the Arg-Val bond in plasminogen to produce active plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins.
Dược Động Học :

▧ Metabolism :
Proteolysis
▧ Route of Elimination :
Urokinase administered by intravenous infusion is rapidly cleared by the liver. Small fractions of the administered dose are excreted in bile and urine
▧ Half Life :
12 minutes. Small fractions of the administered dose are excreted in bile and urine
Chỉ Định : Urokinase can be used for the treatment of pulminary embolism, coronary artery thrombosis, IV catheter clearance, and venous and arterial blood clots.
Tương Tác Thuốc :
  • Aprotinin Aprotonin may antagonize the effect of Urokinase. Monitor for decreased effects of Urokinase.
  • Drotrecogin alfa Increased risk of bleeding.
  • Ginkgo biloba Increased risk of bleeding.
  • Ginseng Increased risk of bleeding.
Liều Lượng & Cách Dùng : Powder, for solution - Intravenous
Dữ Kiện Thương Mại
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00013
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/24430-1003-1
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/X02419
PharmGKB
http://www.pharmgkb.org/drug/PA451836
Wikipedia
http://en.wikipedia.org/wiki/Urokinase
RxList
http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Abbokinase%AE
Drugs.com
http://www.drugs.com/mtm/urokinase.html
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