Tìm theo
Urofollitropin
Các tên gọi khác (7 ) :
  • Follicle Stimulating Hormone
  • Follicle-stimulating hormone beta subunit
  • Follitropin beta chain precursor
  • FSH
  • FSH-B
  • FSH-beta
  • Urofollitrophin
Hormon, Nội tiết tố
Thuốc Gốc
Biotech
CAS: 146479-72-3
ATC: G03GA04
ĐG : Cardinal Health , http://www.cardinal.com
CTHH: C42H65N11O12S2
PTK: 980.1620
Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified. It consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Urofollitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Urofollitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF).
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C42H65N11O12S2
Phân tử khối
980.1620
Độ tan chảy
55 °C
Độ kỵ nước
-0.330
Điểm đẳng điện tích
7.50
Dược Lực Học : Used for the treatment of female infertility, urofollitropin or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of urofollitropin is the primary hormone responsible for follicular recruitment and development.
Cơ Chế Tác Dụng : Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified. It consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Urofollitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Urofollitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
Dược Động Học :
▧ Absorption :
74%
▧ Volume of Distribution :
Time to peak in plasma: IM: 17 hours (single dose), 11 hours (multiple doses) SubQ: 21 hours (single dose), 10 hours (multiple doses)
▧ Route of Elimination :
Via liver and kidneys
▧ Half Life :
Circulation half life of 3-4 hours, elimination half life of 35-40 hours
Chỉ Định : For treatment of female infertility
Liều Lượng & Cách Dùng : Powder, for solution - Intramuscular
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00094
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/55566-8505-2
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/M16647
PharmGKB
http://www.pharmgkb.org/drug/PA451835
Wikipedia
http://en.wikipedia.org/wiki/Urofollitropin
RxList
http://www.rxlist.com/cgi/generic3/urofollitropin.htm
Drugs.com
http://www.drugs.com/cdi/urofollitropin-purified.html
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