Tìm theo
Uric Acid
Các tên gọi khác (3) :
  • 2,6,8-Trihydroxypurine
  • 7,9-dihydro-1H-purine-2,6,8(3H)-trione
  • Urate
Thực phẩm tăng cường hệ miễn dịch
Thuốc Gốc
Small Molecule
CAS: 69-93-2
CTHH: C5H4N4O3
PTK: 168.1103
Uric acid is the last product of purine metabolism in humans. The formation of uric acid is through the enzyme xanthine oxidase, which oxidizes oxypurines. Normally a small amount of uric acid is present in the body, but when there is an excess amount in the blood, called hyperuricemia, this can lead to gout and formation of kidney stones. As a therapeutic agent, it is known that uric acid is increased in response to oxidative stress, and as such, uric acid acts as an antioxidant. At present (August 2013), there is no approved formulation or indication for uric acid. In one country, Spain, uric acid is an investigational drug in a phase 3 trial studying its effects as an adjunct to alteplase in acute ischemic stroke.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H4N4O3
Phân tử khối
168.1103
Monoisotopic mass
168.028340014
InChI
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
InChI Key
InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N
IUPAC Name
2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trione
Traditional IUPAC Name
uric acid
SMILES
O=C1NC2=C(N1)C(=O)NC(=O)N2
Độ tan chảy
Greater than 300 °C
Độ hòa tan
60 mg/L (at 20 °C)
logP
-2.17
logS
-2
pKa (strongest acidic)
7.61
pKa (Strongest Basic)
-6.5
PSA
99.33 Å2
Refractivity
45.63 m3·mol-1
Polarizability
13.61 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
3
H Bond Donor Count
4
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
pKa
5.4
Dược Lực Học : Uric acid is a strong reducing agent (donates electrons) and an antioxidant. Normally in humans, one of the main antioxidants in plasma is uric acid. Several animal studies have found that animals given exogenous uric acid within 3 hours after a stroke had decreased infarct volume, improved neurologic function, and diminished inflammatory responses providing evidence for the neuroprotective effects of uric acid. In some early human studies, uric acid has so far shown similar neuroprotective effects, in both the cortex and subcortex areas, due to its antioxidant effects such as decreased lipid peroxidation, and there appears to be no significant toxicities.
Cơ Chế Tác Dụng : Uric acid is the last product of purine metabolism in humans. The formation of uric acid is through the enzyme xanthine oxidase, which oxidizes oxypurines. Normally a small amount of uric acid is present in the body, but when there is an excess amount in the blood, called hyperuricemia, this can lead to gout and formation of kidney stones. As a therapeutic agent, it is known that uric acid is increased in response to oxidative stress, and as such, uric acid acts as an antioxidant. At present (August 2013), there is no approved formulation or indication for uric acid. In one country, Spain, uric acid is an investigational drug in a phase 3 trial studying its effects as an adjunct to alteplase in acute ischemic stroke. The exact mechanism of action for uric acid's antioxidant effects have not yet been elucidated.
Dược Động Học :

▧ Metabolism :
In higher primates and humans, the enzyme, uricase, is absent, and thus uric acid is not further metabolized and is excreted. In all other mammals, uric acid is metabolized by uricase to allantoin, which is then excreted.
▧ Route of Elimination :
Uric acid is eliminated by the kidneys.
Chỉ Định : At present (August 2013), there is no approved indication for uric acid. The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08844
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00366
Wikipedia
http://en.wikipedia.org/wiki/Uric_acid
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