Tìm theo
Tymazoline
Các tên gọi khác (1) :
  • Thymazen
Thuốc Gốc
Small Molecule
CAS: 24243-97-8
ATC: R01AA13
CTHH: C14H20N2O
PTK: 232.3214
Tymazoline is a nasal preparation.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H20N2O
Phân tử khối
232.3214
Monoisotopic mass
232.157563272
InChI
InChI=1S/C14H20N2O/c1-10(2)12-5-4-11(3)8-13(12)17-9-14-15-6-7-16-14/h4-5,8,10H,6-7,9H2,1-3H3,(H,15,16)
InChI Key
InChIKey=QRORCRWSRPKEHR-UHFFFAOYSA-N
IUPAC Name
2-[5-methyl-2-(propan-2-yl)phenoxymethyl]-4,5-dihydro-1H-imidazole
Traditional IUPAC Name
2-(2-isopropyl-5-methylphenoxymethyl)-4,5-dihydro-1H-imidazole
SMILES
CC(C)C1=C(OCC2=NCCN2)C=C(C)C=C1
Độ hòa tan
1.18e-01 g/l
logP
2.64
logS
-3.3
pKa (Strongest Basic)
7.66
PSA
33.62 Å2
Refractivity
69.54 m3·mol-1
Polarizability
27.29 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Tymazoline is a drug with antihistaminic and sympathomimetic properties. It locally reduces swelling, inflammation and mucosal secretions of the nasal passages.
Cơ Chế Tác Dụng : Tymazoline is a nasal preparation. Thymazen causes vasoconstriction of the nasal mucosa, reducing congestion and thus the swelling of the mucosa. Also reduces the secretions from the nose. Thymazen acts on alpha-adrenergic receptors, which reduces local inflammation of the nasal mucosa especially if their cause is an allergy.
Độc Tính : A large overdose or accidental oral intake, especially in children, may cause excessive sedation with drowsiness, reduced body temperature, heart rate relief and fluctuations in blood pressure and collapse.
Chỉ Định : For the treatment of Inflammation of the lining of the nose and paranasal sinuses and allergic inflammation of nasopharyngeal.
Liều Lượng & Cách Dùng : Liquid - Nasal - 0.5mg/mL
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Thymazen
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08803
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07373
ChemSpider
http://www.chemspider.com/Chemical-Structure.31478.html
PharmGKB
http://www.pharmgkb.org/drug/PA165958422
Wikipedia
http://en.wikipedia.org/wiki/Tymazoline
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