Tìm theo
Tyloxapol
surface active agents, detergents
Thuốc Gốc
Small Molecule
CAS: 25301-02-4
ATC: R05CA01
ĐG : Alcon Laboratories , http://www.alcon.com
Tyloxapol is a non-ionic detergent often used as a surfactant.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
InChI
InChI=1S/C51H80O6/c1-35-25-41(50(13,14)33-47(5,6)7)29-37(44(35)56-23-20-53)27-39-31-42(51(15,16)34-48(8,9)10)30-38(45(39)57-24-21-54)26-36-28-40(17-18-43(36)55-22-19-52)49(11,12)32-46(2,3)4/h17-18,25,28-31,52-54H,19-24,26-27,32-34H2,1-16H3
InChI Key
InChIKey=UTFVNNPSMPINLE-UHFFFAOYSA-N
Dược Lực Học : It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.
Cơ Chế Tác Dụng : Tyloxapol is a non-ionic detergent often used as a surfactant. Tyloxapol, when injected IP, blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. It has also been shown to be inhibitor of lipoprotein lipase, thus preventing triglyceride uptake.
Độc Tính : Acute oral LD50 in 1000 mg/kg in mouse and 5000 mg/kg in rat.
Chỉ Định : Used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions, administered by inhalation through a nebulizer or with a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications.
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Enuclene drops
    Giá bán buôn : USD >0.69
    Đơn vị tính : ml
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Alevaire
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06439
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D03261
ChemSpider
http://www.chemspider.com/Chemical-Structure.11052515.html
PharmGKB
http://www.pharmgkb.org/drug/PA164743726
Wikipedia
http://en.wikipedia.org/wiki/Tyloxapol
Drugs.com
http://www.drugs.com/ingredient/tyloxapol.html
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