Tìm theo
Tripelennamine
Các tên gọi khác (6 ) :
  • PBZ
  • PBZ-sr
  • Tripelennamin
  • Tripelennamina
  • Tripélennamine
  • Tripelennaminum
Thuốc chống dị ứng
Thuốc Gốc
Small Molecule
CAS: 91-81-6
ATC: D04AA04, R06AC04
ĐG : C.O. Truxton Inc.
CTHH: C16H21N3
PTK: 255.358
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H21N3
Phân tử khối
255.358
Monoisotopic mass
255.173547687
InChI
InChI=1S/C16H21N3/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3
InChI Key
InChIKey=UFLGIAIHIAPJJC-UHFFFAOYSA-N
IUPAC Name
N-benzyl-N-[2-(dimethylamino)ethyl]pyridin-2-amine
Traditional IUPAC Name
tripelennamine
SMILES
CN(C)CCN(CC1=CC=CC=C1)C1=CC=CC=N1
Độ hòa tan
587 mg/L (at 30 °C)
logP
3.3
logS
-2.64
pKa (Strongest Basic)
8.76
PSA
19.37 Å2
Refractivity
81.27 m3·mol-1
Polarizability
29.86 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Used to treat the effects of colds and allergies. Tripelennamine is an antihistamine. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Tripelennamine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Cơ Chế Tác Dụng : A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. [PubChem] Tripelennamine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Dược Động Học :
▧ Absorption :
Well absorbed in the digestive tract.
▧ Metabolism :
Hepatic
Độc Tính : Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands and trouble in sleeping.
Chỉ Định : Used for the symptomatic relief of hypersensitivity reactions, coughs, and the common cold.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Cream - Topical
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Tripelennamine hcl powder
    Giá bán buôn : USD >7.35
    Đơn vị tính : g
  • Biệt dược thương mại : Tripelennamine powder
    Giá bán buôn : USD >9.94
    Đơn vị tính : g
  • Biệt dược thương mại : Dehistine syrup
    Giá bán buôn : USD >0.03
    Đơn vị tính : ml
Nhà Sản Xuất
  • Công ty : Chefaro
    Sản phẩm biệt dược : Azaron
  • Công ty : Novartis
    Sản phẩm biệt dược : Pyribenzamine
  • Công ty : Corsa Industries
    Sản phẩm biệt dược : Tripel
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00792
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5587
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506125
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07180
ChemSpider
http://www.chemspider.com/Chemical-Structure.5385.html
PharmGKB
http://www.pharmgkb.org/drug/PA164764429
Wikipedia
http://en.wikipedia.org/wiki/Tripelennamine
Drugs.com
http://www.drugs.com/mtm/tripelennamine.html
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