Tìm theo
Trioxsalen
Các tên gọi khác (11 ) :
  • 2',4,8-Trimethylpsoralen
  • 4,5',8-Trimethylpsoralen
  • 4,8,5'-Trimethylpsoralen
  • 6-Hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone
  • trimethylpsoralen
  • Trioxisaleno
  • Trioxsalen
  • trioxysalen
  • Trioxysalene
  • Trioxysalenum
  • trisoralen
Thuốc cản quang dùng trong chẩn đoán X-Quang
Thuốc Gốc
Small Molecule
CAS: 3902-71-4
ATC: D05AD01
CTHH: C14H12O3
PTK: 228.2433
Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo[1] and hand eczema.[2] After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.[3] The compound is also being explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H12O3
Phân tử khối
228.2433
Monoisotopic mass
228.07864425
InChI
InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3
InChI Key
InChIKey=FMHHVULEAZTJMA-UHFFFAOYSA-N
IUPAC Name
4,7,9-trimethyl-2H-furo[3,2-g]chromen-2-one
Traditional IUPAC Name
lactone
SMILES
CC1=CC2=CC3=C(OC(=O)C=C3C)C(C)=C2O1
Độ tan chảy
234.5 °C
Độ hòa tan
6.27e-02 g/l
logP
2.95
logS
-3.6
pKa (Strongest Basic)
-2.7
PSA
39.44 Å2
Refractivity
64.86 m3·mol-1
Polarizability
24.77 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Trioxsalen ispharmacologically inactive but when exposed to ultraviolet radiation or sunlight it is converted to its active metabolite to produce a beneficial reaction affecting the diseased tissue.
Cơ Chế Tác Dụng : Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo[1] and hand eczema.[2] After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.[3] The compound is also being explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.
Chỉ Định : Trioxsalen is a pigmenting photosensitizing agent used in conjunction with ultraviolet light in the treatment of vitiligo.
Tương Tác Thuốc :
  • Fosphenytoin The hydantoin decreases the effect of psoralene
  • Phenytoin The hydantoin decreases the effect of psoralene
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04571
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C09314
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01034
PharmGKB
http://www.pharmgkb.org/drug/PA164747186
Wikipedia
http://en.wikipedia.org/wiki/Trioxsalen
Drugs.com
http://www.drugs.com/cons/trioxsalen.html
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