Tìm theo
Trimethaphan
Các tên gọi khác (4 ) :
  • Thimethaphan
  • Trimetaphan
  • Trimetaphanum
  • Trimethaphan
antihypertensive agents, adjuvants anesthesia, nicotinic antagonists, ganglionic blockers
Thuốc Gốc
Small Molecule
CAS: 7187-66-8
ATC: C02BA01
CTHH: C22H25N2OS
PTK: 365.512
A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H25N2OS
Phân tử khối
365.512
Monoisotopic mass
365.168759122
InChI
InChI=1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1
InChI Key
InChIKey=CHQOEHPMXSHGCL-UHFFFAOYSA-N
IUPAC Name
3,5-dibenzyl-4-oxo-8$l^{4}-thia-3,5-diazatricyclo[6.3.0.0^{2,6}]undecan-8-ylium
Traditional IUPAC Name
trimethaphan
SMILES
O=C1N(CC2=CC=CC=C2)C2C[S+]3CCCC3C2N1CC1=CC=CC=C1
Độ hòa tan
6.65e-03 g/l
logP
3.473
logS
-4.8
pKa (Strongest Basic)
-2
PSA
23.55 Å2
Refractivity
105.43 m3·mol-1
Polarizability
40.13 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
5
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Trimethaphan is indicated for production of controlled hypotension during surgery to reduce bleeding into the surgical field and also for rapid reduction of blood pressure in the treatment of hypertensive emergencies, especially in patients with acute dissecting aneurysm, and in the emergency treatment of pulmonary edema in patients with pulmonary hypertension associated with systemic hypertension.
Cơ Chế Tác Dụng : A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. [PubChem] Trimethaphan is a ganglionic blocking agent prevents stimulation of postsynaptic receptors by competing with acetylcholine for these receptor sites. Additional effects may include direct peripheral vasodilation and release of histamine. Trimethaphan's hypotensive effect is due to reduction in sympathetic tone and vasodilation, and is primarily postural.
Chỉ Định : For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Arfonad
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01116
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=23576
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508994
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07174
ChemSpider
http://www.chemspider.com/Chemical-Structure.22044.html
PharmGKB
http://www.pharmgkb.org/drug/PA451784
Wikipedia
http://en.wikipedia.org/wiki/Trimethaphan
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