Tìm theo
Trimethadione
Các tên gọi khác (6 ) :
  • Tridione
  • Trimethadion
  • Triméthadione
  • Trimethadionum
  • Trimethinum
  • Troxidone
Thuốc chống co giật, chống động kinh
Thuốc Gốc
Small Molecule
CAS: 127-48-0
ATC: N03AC02
ĐG : Abbott Laboratories Ltd. , http://www.abbott.com
CTHH: C6H9NO3
PTK: 143.1406
An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H9NO3
Phân tử khối
143.1406
Monoisotopic mass
143.058243159
InChI
InChI=1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3
InChI Key
InChIKey=IRYJRGCIQBGHIV-UHFFFAOYSA-N
IUPAC Name
trimethyl-1,3-oxazolidine-2,4-dione
Traditional IUPAC Name
trimethadione
SMILES
CN1C(=O)OC(C)(C)C1=O
Độ tan chảy
46 °C
Độ hòa tan
5E+004 mg/L
logS
0.17
PSA
46.61 Å2
Refractivity
33.2 m3·mol-1
Polarizability
13.59 Å3
logP
0
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications. Dione anticonvulsants are used in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures.
Cơ Chế Tác Dụng : An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
Dược Động Học :

▧ Protein binding :
90%
Độc Tính : Symptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.
Chỉ Định : Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.
Tương Tác Thuốc :
  • Disulfiram Disulfiram, a strong CYP2E1 inhibitor, may decrease the metabolism and clearance of Trimethadione, a CYP2E1 substrate. Consider alternate therapy or monitor for changes in Trimethadione therapeutic and adverse effects if Disulfiram is initiated, discontinued or dose changed.
  • Triprolidine The CNS depressants, Triprolidine and Trimethadione, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Sản phẩm biệt dược : Minoale
  • Công ty : Abbott
    Sản phẩm biệt dược : Tridione
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00347
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5576
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504478
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00392
ChemSpider
http://www.chemspider.com/Chemical-Structure.5374.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019167
PharmGKB
http://www.pharmgkb.org/drug/PA164744924
Wikipedia
http://en.wikipedia.org/wiki/Trimethadione
Drugs.com
http://www.drugs.com/mtm/trimethadione.html
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