Tìm theo
Trilostane
Các tên gọi khác (2) :
  • Trilostano
  • Trilostanum
anti adrenal agents, anticorticosteroid
Thuốc Gốc
Small Molecule
CAS: 13647-35-3
ATC: H02CA01
CTHH: C20H27NO3
PTK: 329.4333
Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H27NO3
Phân tử khối
329.4333
Monoisotopic mass
329.199093735
InChI
InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
InChI Key
InChIKey=KVJXBPDAXMEYOA-CXANFOAXSA-N
IUPAC Name
(1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.0^{2,8}.0^{6,8}.0^{12,16}]octadec-4-ene-4-carbonitrile
Traditional IUPAC Name
trilostane
SMILES
[H][C@]12O[C@]11CC[C@@]3([H])[C@]4([H])CC[C@H](O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC(C#N)=C2O
Độ tan chảy
264 dec °C
Độ hòa tan
5.93e-02 g/l
logP
3
logS
-3.8
pKa (strongest acidic)
5.23
pKa (Strongest Basic)
-0.88
PSA
76.78 Å2
Refractivity
90.17 m3·mol-1
Polarizability
36.96 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
5
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland. This product was withdrawn from the U.S. market in April 1994.
Cơ Chế Tác Dụng : Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994. [Wikipedia] Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Dược Động Học :

▧ Metabolism :
Hepatic.
▧ Half Life :
8 hours.
Độc Tính : Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
Chỉ Định : Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Desopan
  • Công ty :
    Sản phẩm biệt dược : Modrastane
  • Công ty :
    Sản phẩm biệt dược : Modrenal
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01108
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=656583
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507062
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01180
ChemSpider
http://www.chemspider.com/Chemical-Structure.570949.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748507
Wikipedia
http://en.wikipedia.org/wiki/Trilostane
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