Tìm theo
Trihexyphenidyl
Các tên gọi khác (7 ) :
  • (RS)-1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol
  • Apo-trihex
  • Benzhexol Hydrochloride
  • Trihexifenidilo
  • Trihexyphenidyl
  • Trihexyphénidyle
  • Trihexyphenidylum
Thuốc chống Parkinson
Thuốc Gốc
Small Molecule
CAS: 144-11-6
ATC: N04AA01
ĐG : Advanced Pharmaceutical Services Inc.
CTHH: C20H31NO
PTK: 301.4662
One of the centrally acting muscarinic antagonists used for treatment of parkinsonian disorders and drug-induced extrapyramidal movement disorders and as an antispasmodic. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H31NO
Phân tử khối
301.4662
Monoisotopic mass
301.240564619
InChI
InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2
InChI Key
InChIKey=HWHLPVGTWGOCJO-UHFFFAOYSA-N
IUPAC Name
1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol
Traditional IUPAC Name
trihexyphenidyl
SMILES
OC(CCN1CCCCC1)(C1CCCCC1)C1=CC=CC=C1
Độ tan chảy
258.5 °C
Độ hòa tan
3.14e-03 g/l
logP
4.49
logS
-5
pKa (strongest acidic)
13.84
pKa (Strongest Basic)
9.32
PSA
23.47 Å2
Refractivity
93.21 m3·mol-1
Polarizability
36.73 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Trihexyphenidyl is an anticholinergic used in the symptomatic treatment of all etiologic groups of parkinsonism and drug induced extrapyramidal reactions (except tardive dyskinesia). Trihexyphenidyl possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of parkinsonism.
Cơ Chế Tác Dụng : One of the centrally acting muscarinic antagonists used for treatment of parkinsonian disorders and drug-induced extrapyramidal movement disorders and as an antispasmodic. [PubChem] Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.
Dược Động Học :
▧ Absorption :
Trihexyphenidyl is rapidly absorbed from the gastrointestinal tract.
▧ Half Life :
3.3-4.1 hours
Độc Tính : Symptoms of overdose include mydriasis, dryness of mucous membranes, red face, atonic states of bowels and bladder, and hyperthermia in high doses. Central consequences are agitation, confusion, and hallucinations. An untreated overdose may be fatal, particular in children. Premortal signs are respiratory depression and cardiac arrest.
Chỉ Định : Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.
Tương Tác Thuốc :
  • Donepezil Possible antagonism of action
  • Galantamine Possible antagonism of action
  • Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
  • Potassium Chloride The ulcerative effects of solid oral dosage forms of KCl may be enhanced by Trihexyphenidyl, an anticholinergic. Anticholinergics slow gastric emptying, increasing the contact time between the gastrointestinal mucosa and KCl. Prolonged exposure to KCl increases the risk of gastric and intestinal irritation and ulceration. Solid oral dosage forms of KCl should be avoided; alternatives include liquid or effervescent potassium preparations.
  • Pramlintide The anticholinergic effects of Trihexyphenidyl may be enhanced by Pramlintide. Additive effects of reduced GI motility may occur. Pramlintide slows gastic emptying and should not be used with drugs that alter GI motility (e.g. anticholinergics). Consider alternative treatments or use caution during concomitant therapy.
  • Rivastigmine Possible antagonism of action
  • Secretin The stimulatory effect of Secretin may be reduced by anticholinergics such as Trihexyphenidyl. Concomitant use of Secretin and drugs with substantial anticholinergic effects should be avoided. If combination therapy must be used, Secretin efficacy should be closely monitored.
  • Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Trihexyphenidyl, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
  • Trimethobenzamide Trimethobenzamide and Trihexyphenidyl, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Triprolidine Triprolidine and Trihexyphenidyl, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Trospium Trospium and Trihexyphenidyl, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Liều Lượng & Cách Dùng : Elixir - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Atlantic
    Sản phẩm biệt dược : ACA
  • Công ty : Medifive
    Sản phẩm biệt dược : Acamed
  • Công ty : Panbiotic
    Sản phẩm biệt dược : Altant
  • Công ty : Sanofi Aventis
    Sản phẩm biệt dược : Artane
  • Công ty : The Central
    Sản phẩm biệt dược : Artine
  • Công ty : Newai Chem
    Sản phẩm biệt dược : Atan
  • Công ty : Johnson
    Sản phẩm biệt dược : Benzhexol
  • Công ty : Li Ta
    Sản phẩm biệt dược : Benzox
  • Công ty : Intas
    Sản phẩm biệt dược : Bexol
  • Công ty : Alliance
    Sản phẩm biệt dược : Broflex
  • Công ty : Grindeks
    Sản phẩm biệt dược : Cyclodol
  • Công ty : Crescent
    Sản phẩm biệt dược : Dyskinil
  • Công ty : Heng Hsin
    Sản phẩm biệt dược : Ea Ten
  • Công ty : Mersifarma
    Sản phẩm biệt dược : Hexymer
  • Công ty : Psicofarma
    Sản phẩm biệt dược : Hipokinon
  • Sản phẩm biệt dược : Lahexy
  • Công ty : Wyeth
    Sản phẩm biệt dược : Pacitane
  • Công ty : Takata Seiyaku
    Sản phẩm biệt dược : Pakisonal
  • Công ty : Psyco Remedies
    Sản phẩm biệt dược : Parales
  • Công ty : Milve
    Sản phẩm biệt dược : Parcisol
  • Công ty : Nevada Pharma
    Sản phẩm biệt dược : Pargitan
  • Công ty : Micro Synapse
    Sản phẩm biệt dược : Parkin
  • Công ty : Eisai
    Sản phẩm biệt dược : Parkinane
  • Công ty : Towa Yakuhin
    Sản phẩm biệt dược : Parkines
  • Công ty : CCPC
    Sản phẩm biệt dược : Parkinidyl
  • Công ty : Balkanpharma
    Sản phẩm biệt dược : Parkisan
  • Công ty : Sun
    Sản phẩm biệt dược : Parkitane
  • Công ty : Hikma
    Sản phẩm biệt dược : Parkizol
  • Công ty : Chile
    Sản phẩm biệt dược : Tonaril
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00376
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5572
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507717
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07171
ChemSpider
http://www.chemspider.com/Chemical-Structure.5371.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/61748-054-36
PharmGKB
http://www.pharmgkb.org/drug/PA164747026
Wikipedia
http://en.wikipedia.org/wiki/Trihexyphenidyl
RxList
http://www.rxlist.com/cgi/generic3/trihexyphen.htm
Drugs.com
http://www.drugs.com/cdi/trihexyphenidyl.html
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