Tìm theo
Tridihexethyl
cholinergic antagonists, antispasmodics
Thuốc Gốc
Small Molecule
CAS: 60-49-1
ATC: A03AB08
CTHH: C21H36NO
PTK: 318.5166
Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug. Tridihexethyl is no longer available in the US market.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H36NO
Phân tử khối
318.5166
Monoisotopic mass
318.279689779
InChI
InChI=1S/C21H36NO/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3/q+1
InChI Key
InChIKey=NPRHVSBSZMAEIN-UHFFFAOYSA-N
IUPAC Name
(3-cyclohexyl-3-hydroxy-3-phenylpropyl)triethylazanium
Traditional IUPAC Name
tridihexethyl
SMILES
CC[N+](CC)(CC)CCC(O)(C1CCCCC1)C1=CC=CC=C1
Độ tan chảy
181.5 °C
Độ hòa tan
11 mg/mL
logP
1.17
logS
-7.3
pKa (strongest acidic)
13.69
pKa (Strongest Basic)
-3.4
PSA
20.23 Å2
Refractivity
111.22 m3·mol-1
Polarizability
39.17 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug.
Cơ Chế Tác Dụng : Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug. Tridihexethyl is no longer available in the US market. Tridihexethyl binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Tridihexethyl inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
Chỉ Định : Used as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus
Tương Tác Thuốc :
  • Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Pathilon
  • Công ty :
    Sản phẩm biệt dược : Propethonum
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00505
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=20299
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506672
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07861
ChemSpider
http://www.chemspider.com/Chemical-Structure.19124.html
PharmGKB
http://www.pharmgkb.org/drug/PA164746229
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