Dược Động Học :
▧ Absorption :
Systemically absorbed when administered to the eye.
▧ Metabolism :
Travoprost, an isopropyl ester prodrug, is hydrolyzed by esterases in the cornea to its biologically active free acid. Systemically, travoprost free acid is metabolized to inactive metabolites via beta-oxidation of the α(carboxylic acid) chain to give the 1,2-dinor and 1,2,3,4-tetranor analogs, via oxidation of the 15-hydroxyl moiety, as well as via reduction of the 13,14 double bond.
▧ Route of Elimination :
Less than 2% of the topical ocular dose of travoprost was excreted in the urine within 4 hours as the travoprost free acid.
▧ Half Life :
Terminal elimination half-life of travoprost free acid is 45 minutes.