Tìm theo
Tolnaftate
Các tên gọi khác (10 ) :
  • 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate
  • m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester
  • Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester
  • N-Methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
  • O-2-Naphthyl m,N-dimethylthiocarbanilate
  • Separin
  • Tinactin
  • Tolnaftato
  • Tolnaftatum
  • Tolnaphthate
antifungal agents
Thuốc Gốc
Small Molecule
CAS: 2398-96-1
ATC: D01AE18
ĐG : Chain Drug , http://www.chaindrug.com
CTHH: C19H17NOS
PTK: 307.409
Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H17NOS
Phân tử khối
307.409
Monoisotopic mass
307.103084861
InChI
InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
InChI Key
InChIKey=FUSNMLFNXJSCDI-UHFFFAOYSA-N
IUPAC Name
N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
Traditional IUPAC Name
tolnaftate
SMILES
CN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1
Độ tan chảy
111 °C
Độ hòa tan
7.02e-05 mg/mL at 25 °C
logP
5.1
logS
-5.8
pKa (Strongest Basic)
0.075
PSA
12.47 Å2
Refractivity
94.92 m3·mol-1
Polarizability
34.22 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Dược Lực Học : Tolnaftate is a synthetic over-the-counter anti-fungal agent.
Cơ Chế Tác Dụng : Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters. Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
Độc Tính : Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
Chỉ Định : Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
Liều Lượng & Cách Dùng : Aerosol - Topical
Cream - Topical
Gel - Topical
Liquid - Topical
Powder - Topical
Spray - Topical
Swab - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Aftate
  • Công ty :
    Sản phẩm biệt dược : Dr. Scholl's athlete's foot spray
  • Công ty :
    Sản phẩm biệt dược : Genaspor
  • Công ty :
    Sản phẩm biệt dược : Lamisil AF
  • Công ty :
    Sản phẩm biệt dược : NP-27
  • Công ty :
    Sản phẩm biệt dược : Odor Eaters
  • Công ty :
    Sản phẩm biệt dược : Pitrex
  • Công ty :
    Sản phẩm biệt dược : Separin
  • Công ty :
    Sản phẩm biệt dược : Tinactin
  • Công ty :
    Sản phẩm biệt dược : Tinaderm
  • Công ty :
    Sản phẩm biệt dược : Ting
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00525
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5510
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505456
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00381
ChemSpider
http://www.chemspider.com/Chemical-Structure.5309.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201633
PharmGKB
http://www.pharmgkb.org/drug/PA164752438
Wikipedia
http://en.wikipedia.org/wiki/Tolnaftate
Drugs.com
http://www.drugs.com/cdi/tolnaftate-cream.html
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