Tìm theo
Tolazoline
Các tên gọi khác (9 ) :
  • 2-Benzyl-2-imidazoline
  • 2-Benzyl-4,5-imidazoline
  • 2-Benzylimidazoline
  • 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole
  • Benzazolin
  • Tolazolin
  • Tolazolina
  • Tolazoline
  • Tolazolinum
antihypertensive agents, vasodilator agents, adrenergic alpha antagonists
Thuốc Gốc
Small Molecule
CAS: 59-98-3
ATC: C04AB02, M02AX02
ĐG : Novartis AG , http://www.novartis.com
CTHH: C10H12N2
PTK: 160.2157
A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H12N2
Phân tử khối
160.2157
Monoisotopic mass
160.100048394
InChI
InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)
InChI Key
InChIKey=JIVZKJJQOZQXQB-UHFFFAOYSA-N
IUPAC Name
2-benzyl-4,5-dihydro-1H-imidazole
Traditional IUPAC Name
tolazoline
SMILES
C(C1=NCCN1)C1=CC=CC=C1
Độ tan chảy
174 °C
Độ hòa tan
373 mg/L
logP
2.65
logS
-2.1
pKa (Strongest Basic)
10.25
PSA
24.39 Å2
Refractivity
49.07 m3·mol-1
Polarizability
17.94 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
10.3
Dược Lực Học : Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).
Cơ Chế Tác Dụng : A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. [PubChem] Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.
Chỉ Định : For the treatment of pulmonary artery anomalies
Tương Tác Thuốc :
  • Cimetidine Anticipated loss of efficacy of tolazoline
  • Ranitidine Anticipated loss of efficacy of tolazoline
  • Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00797
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5504
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505641
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07147
ChemSpider
http://www.chemspider.com/Chemical-Structure.5303.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0083-6733-04
PharmGKB
http://www.pharmgkb.org/drug/PA451716
Wikipedia
http://en.wikipedia.org/wiki/Tolazoline
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