Tìm theo
Ticarcillin
Các tên gọi khác (6 ) :
  • (2S,5R,6R)-6-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • alpha-Carboxy-3-thienylmethylpenicillin
  • Ticarcilina
  • Ticarcillin supplement
  • Ticarcilline
  • Ticarcillinum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 34787-01-4
ATC: J01CA13
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C15H16N2O6S2
PTK: 384.427
An antibiotic derived from penicillin similar to carbenicillin in action.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H16N2O6S2
Phân tử khối
384.427
Monoisotopic mass
384.044977634
InChI
InChI=1S/C15H16N2O6S2/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23)/t7-,8-,9+,12-/m1/s1
InChI Key
InChIKey=OHKOGUYZJXTSFX-KZFFXBSXSA-N
IUPAC Name
(2S,5R,6R)-6-[(2R)-2-carboxy-2-(thiophen-3-yl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Traditional IUPAC Name
ticarcillin
SMILES
[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](C(O)=O)C1=CSC=C1)C(O)=O
Độ hòa tan
7.16e-02 g/l
logP
0.6
logS
-3.7
pKa (strongest acidic)
3.09
pKa (Strongest Basic)
-6.3
PSA
124.01 Å2
Refractivity
87.93 m3·mol-1
Polarizability
36.14 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
6
H Bond Donor Count
3
Physiological Charge
-2
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcillin is, however, susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes.
Cơ Chế Tác Dụng : An antibiotic derived from penicillin similar to carbenicillin in action. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis when the bacteria tries to divide, causing death.
Dược Động Học :

▧ Protein binding :
45%
▧ Half Life :
1.1 hours
Độc Tính : As with other penicillins, neurotoxic reactions may arise when very high doses of ticarcillin are administered, especially in patients with impaired renal function.
Chỉ Định : For the treatment of bacterial infections.
Tương Tác Thuốc :
  • Amikacin Ticarcillin may reduce the serum concentration of Amikacin. Ticarcillin may inactivate Amikacin in vitro and the two agents should not be administered simultaneously through the same IV line.
  • Demeclocycline Demeclocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Demeclocycline.
  • Doxycycline Doxycycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Doxycycline.
  • Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
  • Fusidic Acid Fusidic acid may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Fusidic acid.
  • Gentamicin Ticarcillin may reduce the serum concentration of Gentamicin. Ticarcillin may inactivate Gentamicin in vitro and the two agents should not be administered simultaneously through the same IV line.
  • Kanamycin Ticarcillin may reduce the serum concentration of Kanamycin. Ticarcillin may inactivate Kanamycin in vitro and the two agents should not be administered simultaneously through the same IV line.
  • Methotrexate The penicillin increases the effect and toxicity of methotrexate
  • Minocycline Minocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Minocycline.
  • Neomycin Ticarcillin may reduce the serum concentration of Neomycin. Ticarcillin may inactivate Neomycin in vitro and the two agents should not be administered simultaneously through the same IV line.
  • Oxytetracycline Oxytetracycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Oxytetracycline.
  • Streptomycin Ticarcillin may reduce the serum concentration of Streptomycin. Ticarcillin may inactivate Streptomycin in vitro and the two agents should not be administered simultaneously through the same IV line.
  • Tetracycline Tetracycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Tetracycline.
  • Tobramycin Ticarcillin may reduce the serum concentration of Tobramycin. Ticarcillin may inactivate Tobramycin in vitro and the two agents should not be administered simultaneously through the same IV line.
Dữ Kiện Thương Mại
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01607
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=36921
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505959
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07139
ChemSpider
http://www.chemspider.com/Chemical-Structure.33876.html
PharmGKB
http://www.pharmgkb.org/drug/PA451684
Wikipedia
http://en.wikipedia.org/wiki/Ticarcillin
RxList
http://www.rxlist.com/cgi/generic/timentin.htm
Drugs.com
http://www.drugs.com/cdi/ticarcillin.html
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