Tìm theo
Tetrahydrofolic acid
Các tên gọi khác (8 ) :
  • (6S)-Tetrahydrofolate
  • (6S)-Tetrahydrofolic acid
  • (6S)-THFA
  • 5,6,7,8-tetrahydrofolate
  • 5,6,7,8-tetrahydrofolic acid
  • tetrahydrofolate
  • Tetrahydrofolic acid
  • THF
dietary supplements, micronutrients, supplements
Thuốc Gốc
Small Molecule
CAS: 135-16-0
CTHH: C19H23N7O6
PTK: 445.4292
Tetrahydrofolic acid is a folic acid derivative. It is produced from dihydrofolic acid by dihydrofolate reductase. It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H23N7O6
Phân tử khối
445.4292
Monoisotopic mass
445.170981503
InChI
InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1
InChI Key
InChIKey=MSTNYGQPCMXVAQ-KIYNQFGBSA-N
IUPAC Name
(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
Traditional IUPAC Name
tetrahydrofolic acid
SMILES
NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1
Độ hòa tan
2.69e-01 g/l
logP
-2.7
logS
-3.2
pKa (strongest acidic)
3.51
pKa (Strongest Basic)
3.58
PSA
207.27 Å2
Refractivity
121.39 m3·mol-1
Polarizability
42.95 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
12
H Bond Donor Count
8
Physiological Charge
-2
Number of Rings
3
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Tetrahydrofolate is the main active metabolite of dietary folate. It is vital as a coenzyme in reactions involving transfers of single carbon groups. Tetrahydrofolate has a role in nucleic and amino acid synthesis. As nucleic and amino acid synthesis is affected by a deficiency of tetrahydrofolate, actively dividing and growing cells tend to be the first affected. Tetrahydrofolate is used to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid.
Cơ Chế Tác Dụng : Tetrahydrofolic acid is a folic acid derivative. It is produced from dihydrofolic acid by dihydrofolate reductase. It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes. Tetrahydrofolate is transported across cells by receptor-mediated endocytosis where it is needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate.
Chỉ Định : For nutritional supplementation, also for treating dietary shortage or imbalance.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00116
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=91443
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504756
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00101
ChemSpider
http://www.chemspider.com/Chemical-Structure.82572.html
PharmGKB
http://www.pharmgkb.org/drug/PA164745110
Wikipedia
http://en.wikipedia.org/wiki/Tetrahydrofolic_acid
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