Tìm theo
Tetraethylammonium
Các tên gọi khác (1) :
  • TEA
potassium channel blockers
Thuốc Gốc
Small Molecule
CAS: 66-40-0
CTHH: C8H20N
PTK: 130.2511
Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. As an experimental agent, tetraethylammonium is used in its salt forms such as tetraethylammonium chloride and tetraethylammonium bromide. Its mechanism of action is still being investigated, but it is known that tetraethylammonium blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors. Because of its inhibitory actions at the autonomic ganglia, tetraethylammonium was thought to be a potential therapeutic vasodilator but serious toxic effects were found. The most common use of tetraethylammonium presently is as a pharmacological research agent that blocks selective potassium channels. Structurally, tetraethylammonium is positively charged due to its central quaternary ammonium.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H20N
Phân tử khối
130.2511
Monoisotopic mass
130.159574645
InChI
InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1
InChI Key
InChIKey=CBXCPBUEXACCNR-UHFFFAOYSA-N
IUPAC Name
tetraethylazanium
Traditional IUPAC Name
tetraethylammonium
SMILES
CC[N+](CC)(CC)CC
Độ tan chảy
360 °C or 680 °F
Độ hòa tan
Soluble in water.
logP
-2.5
logS
-4.8
Refractivity
54.9 m3·mol-1
Polarizability
17.32 Å3
Polar Surface Area (PSA)
0
Rotatable Bond Count
4
H Bond Acceptor Count
0
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Tetraethylammonium is a vasodilator because it blocks autonomic ganglia and prevents signals carrying vasoconstrictor impulses from proceeding.
Cơ Chế Tác Dụng : Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. As an experimental agent, tetraethylammonium is used in its salt forms such as tetraethylammonium chloride and tetraethylammonium bromide. Its mechanism of action is still being investigated, but it is known that tetraethylammonium blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors. Because of its inhibitory actions at the autonomic ganglia, tetraethylammonium was thought to be a potential therapeutic vasodilator but serious toxic effects were found. The most common use of tetraethylammonium presently is as a pharmacological research agent that blocks selective potassium channels. Structurally, tetraethylammonium is positively charged due to its central quaternary ammonium. Tetraethylammonium's mechanism of action is still being investigated, but it is known that it blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors.
Dược Động Học :

▧ Route of Elimination :
Tetraethylammonium is eliminated by active renal tubular secretion by the cation transport system.
Độc Tính : Studies in animals and humans have reported cases of serious muscle paralysis, which can lead to respiratory distress and death.
Chỉ Định : Tetraethylammonium is an experimental drug with no approved indication.
Liều Lượng & Cách Dùng : Injection - Intravenous
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08837
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07512
Wikipedia
http://en.wikipedia.org/wiki/Tetraethylammonium
... loading
... loading