Tìm theo
Teicoplanin
Các tên gọi khác (3) :
  • TEIC
  • Teichomycin
  • Teichomycin a2 factor 2
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Biotech
CAS: 61036-62-2
ATC: J01XA02
CTHH: C88H97Cl2N9O33
PTK: 1879.6580
Teicoplanin is a glycopeptide antibiotic. It is a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). All teicoplanins share a same glycopeptide core, termed teicoplanin A3-1, a fused ring structure to which two carbohydrates (mannose and N-acetylglucosamine) are attached. The major and minor components also contain a third carbohydrate moiety, β-D-glucosamine, and differ only by the length and conformation of a side chain attached to it. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C88H97Cl2N9O33
Phân tử khối
1879.6580
Dược Lực Học : Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. It is a glycopeptide antiobiotic extracted from Actinoplanes teichomyceticus, with a similar spectrum of activity to vancomycin. Its mechanism of action is to inhibit bacterial cell wall synthesis. Oral teicoplanin has been demonstrated to be effective in the treatment of pseudomembranous colitis and Clostridium difficile-associated diarrhoea, with comparable efficacy to vancomycin.
Cơ Chế Tác Dụng : Teicoplanin is a glycopeptide antibiotic. It is a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). All teicoplanins share a same glycopeptide core, termed teicoplanin A3-1, a fused ring structure to which two carbohydrates (mannose and N-acetylglucosamine) are attached. The major and minor components also contain a third carbohydrate moiety, β-D-glucosamine, and differ only by the length and conformation of a side chain attached to it. [Wikipedia] Teicoplanin inhibits peptidoglycan polymerization, resulting in inhibition of bacterial cell wall synthesis and cell death.
Dược Động Học :
▧ Absorption :
Teicoplanin is poorly absorbed after oral administration but is 90% bioavailable when administered intramuscularly.
▧ Protein binding :
90% to 95%
▧ Metabolism :
Two metabolites (metabolites 1 and 2; 2 to 3% of total teicoplanin) have been isolated after intravenous administration of radiolabeled teicoplanin. After purification, their structures were found to be new teicoplanin-like molecules, bearing 8-hydroxydecanoic and 9-hydroxydecanoic acyl moieties. This metabolic transformation is likely due to hydroxylation in the omega-2 and omega-1 positions for metabolites 1 and 2, respectively, of the C-10 linear side chain of component A2-3. This might explain the low extent of metabolism of teicoplanin if we consider that only component A2-3 has a linear chain that is susceptible to such oxidation.
▧ Half Life :
70-100 hours
Chỉ Định : For the treatment of bacterial infections caused by susceptible microorganisms.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06149
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C15820
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02142
PharmGKB
http://www.pharmgkb.org/drug/PA164746244
Wikipedia
http://en.wikipedia.org/wiki/Teicoplanin
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